使用血流分流装置治疗血泡样动脉瘤的特征、管理和临床疗效的比较分析:对 30 项研究的系统回顾和荟萃分析。

IF 12.5 2区 医学 Q1 SURGERY International journal of surgery Pub Date : 2024-09-17 DOI:10.1097/JS9.0000000000002072
Dianshi Jin, Zheming Zhang, Xin Su, Guoliang Li
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引用次数: 0

摘要

背景和目的:由于使用血流分流器(FD)治疗血泡样动脉瘤(BBA)的数据相对较少,现有研究未能对该疾病的特征、管理、临床结果进行全面分析。因此,我们收集并分析了现有证据,旨在对使用分流装置治疗水泡样动脉瘤的管理、并发症、临床和血管造影结果以及预后风险因素进行定量汇总:方法:对截至 2024 年 5 月 1 日的 PubMed、SCOPUS、Cochrane Library 和 Web of Science 进行了系统检索,以寻找相关研究。主要研究结果是阐述使用FD装置治疗BBA的管理、特征和临床结果。次要研究结果是确定使用 FD 设备治疗的 BBA 在特征和结果以及风险因素方面的差异。两名审稿人独立评估试验质量并提取数据。所有统计分析均使用 Review Manager 5.2 和 Stata 12.0 中提供的标准统计程序进行:共发现了 30 份报告,涉及 311 名 783 例 BBA 患者。汇总结果显示,76.3%的BBA位于颈内动脉(ICA),85%和84%的患者在随访时分别出现完全闭塞和改良Rankin量表(mRS)0-2分。BBAs患者中女性居多(69.9%),88.5%的患者出院时预后良好。总并发症和围手术期并发症分别占16.8%和9.1%。汇总结果显示,在即时、短期和长期血管造影结果中,完全闭塞的发生率分别为 50%(95% CI:31%-69%)、80%(95% CI:67%-92%)和 84%(95% CI:77%-91%)。此外,用 mRS 评估的良好、中度和不良临床结果分别为 89% (95% CI:85%-94%)、13% (95% CI:5%-21%)和 8% (95% CI:3%-13%)。我们发现,与中度或不良预后相比,预后良好的患者术前评分显著降低(MD-1.24;95% CI-1.94--0.53),闭塞更完全(OR 5.17;95% CI 1.26-21.15),并发症更少(OR 0.20;95% CI 0.08-0.47)。据观察,出现并发症的患者的 Hunt-Hess 评分(MD 0.49;95% CI 0.03-0.96)和 Fisher 评分(MD 1.43;95% CI 0.72-2.13)分别较高。结果良好的患者年龄较小(MD -5.76岁;95% CI -11.31--0.21),Hunt-Hess评分较低(MD -0.96;95% CI -1.45--0.47 ):结论:BBA以中年女性为主,常见于ICA。结论:BBA 以中年女性为主,在 ICA 中很常见,大多数患者的预后良好,围手术期并发症发生率较低。此外,较低的术前评分、较完全的闭塞、较少的并发症和较小的年龄也有利于良好的预后。较高的 Hunt-Hess 评分和 Fisher 评分可能会增加并发症的风险。未来的研究需要足够的样本量和长期的随访,以明确BBA的管理、长期疗效和风险因素。
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Comparative analysis of characteristics, management and clinical outcome of blood blister-like aneurysms treated with flow diverter devices: a systematic review and meta-analysis of 30 studies.

Background and aim: Because of relatively little data for blood blister-like aneurysms (BBAs) treated with flow diverter (FD) devices, existing studies failed to provide comprehensive analysis for the characteristics, management, clinical outcome of the disease. Therefore, we collected and analyzed current evidence aiming to provide quantitatively pooled results for the management, complication, clinical and angiographic outcomes as well as the risk factors of prognosis of BBAs treated with FD devices.

Methods: A systematic search of PubMed, SCOPUS, Cochrane Library and Web of Science up to May 1, 2024 was conducted for relevant studies. The primary outcomes were to expound the management, characteristics and clinical outcomes of BBAs treated with FD devices. The secondary outcomes were to determine the difference of characteristics and outcomes, as well as risk factors of BBAs treated with FD devices. Two reviewers assessed trial quality and extracted the data independently. All statistical analyses were performed using the standard statistical procedures provided in Review Manager 5.2 and Stata 12.0.

Results: A total of 30 reports with 311 of 783 BBA patients were identified. The pooled results indicated that 76.3% BBAs located in internal carotid artery (ICA) and 85% and 84% patients experienced complete occlusion and modified Rankin scale (mRS) score 0-2 respectively at follow-up time. Female BBAs patients (69.9%) were more prevalent and 88.5% patients experienced a favorable outcome at discharge. The overall and periprocedural complications account for 16.8% and 9.1% respectively. The pooled results showed that the incidence of complete occlusion was 50% (95% CI: 31%-69%), 80% (95% CI: 67%-92%) and 84% (95% CI: 77%-91%) at immediate, short and longterm angiographic results respectively. In addition, the favorable, moderate and poor clinical outcomes evaluated with mRS were 89% (95% CI: 85%-94%), 13% (95% CI: 5%-21%), and 8% (95% CI: 3%-13%) respectively. We found that compared to moderate or poor outcomes, patients with good outcomes experienced significantly lower preoperative scores (MD -1.24; 95% CI -1.94--0.53), more complete occlusion (OR 5.17; 95% CI 1.26-21.15) and less complications (OR 0.20; 95% CI 0.08-0.47) respectively. It was observed that patients experienced a complication had higher onset Hunt-Hess scale (MD 0.49; 95% CI 0.03-0.96) and Fisher's score (MD 1.43; 95% CI 0.72-2.13) respectively. Patients with good outcomes experienced younger age (MD -5.76 years; 95% CI -11.31--0.21) and lower onset Hunt-Hess scale (MD -0.96; 95% CI -1.45--0.47) respectively.

Conclusions: BBA was middle-aged female predominant and common in ICA. The majority of patients generally experienced favorable outcome with low incidence of periprocedural complications. In addition, good outcomes benefited from lower preoperative scores, more complete occlusion, less complications and younger age. Higher onset Hunt-Hess scale and Fisher's score may increase the risk of complications. Future studies with enough sample size and long follow-up are required to clear the management, long-term outcome and risk factors of BBAs.

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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
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