英国种族与多发性硬化症特征之间的关系:英国多发性硬化症登记研究。

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI:10.1177/13524585241277018
Benjamin M Jacobs, Luisa Schalk, Emily Tregaskis-Daniels, Pooja Tank, Sadid Hoque, Michelle Peter, Katherine Tuite-Dalton, James Witts, Riley Bove, Ruth Dobson
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引用次数: 0

摘要

背景:先前的研究表明,多发性硬化症(MS)的严重程度因种族而异:以前的研究表明,多发性硬化症(MS)的严重程度因种族而异:数据来自英国多发性硬化症登记册,这是一项针对多发性硬化症患者的前瞻性纵向队列研究。我们研究了自我报告的种族背景与发病年龄、发病症状和参与者报告的各种严重程度之间的关系。我们使用调整后的多变量线性回归模型来探讨种族与多发性硬化症影响之间的关系,并使用 Cox 比例危险模型来评估残疾进展:我们分析了 17,314 名多发性硬化症患者的数据,其中包括自述为黑人(157 人)或南亚人(230 人)的患者。与白人(中位数 35.0)相比,南亚裔(中位数 30.0)和黑人(中位数 33.0)患者的多发性硬化症发病和诊断年龄较低。在可在线测量多发性硬化症严重程度的参与者中,我们在横向和纵向分析中均未发现种族背景与多发性硬化症身体残疾之间存在统计学意义上的显著关联:我们发现,在一个大型、多样化的英国队列中,种族背景与多发性硬化症严重程度之间没有关联。这些研究结果表明,社会经济地位和结构不平等等其他因素可能解释了之前的研究结果。
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The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study.

Background: Previous studies have suggested differences in multiple sclerosis (MS) severity according to ethnicity.

Methods: Data were obtained from the UK MS Register, a prospective longitudinal cohort study of persons with MS. We examined the association between self-reported ethnic background and age at onset, symptom of onset and a variety of participant-reported severity measures. We used adjusted multivariable linear regression models to explore the association between ethnicity and impact of MS, and Cox proportional hazards models to assess disability progression.

Results: We analysed data from 17,314 people with MS, including participants from self-reported Black (n = 157) or South Asian (n = 230) ethnic backgrounds. Age at MS onset and diagnosis was lower in those of South Asian (median 30.0) and Black (median 33.0) ethnicity compared with White ethnicity (median 35.0). In participants with online MS severity measures available, we found no statistically significant evidence for an association between ethnic background and physical disability in MS in both cross-sectional and longitudinal analyses.

Conclusion: We found no association between ethnic background and MS severity in a large, diverse UK cohort. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings.

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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
期刊最新文献
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