英国种族与多发性硬化症特征之间的关系:英国多发性硬化症登记研究。

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI:10.1177/13524585241277018
Benjamin M Jacobs, Luisa Schalk, Emily Tregaskis-Daniels, Pooja Tank, Sadid Hoque, Michelle Peter, Katherine Tuite-Dalton, James Witts, Riley Bove, Ruth Dobson
{"title":"英国种族与多发性硬化症特征之间的关系:英国多发性硬化症登记研究。","authors":"Benjamin M Jacobs, Luisa Schalk, Emily Tregaskis-Daniels, Pooja Tank, Sadid Hoque, Michelle Peter, Katherine Tuite-Dalton, James Witts, Riley Bove, Ruth Dobson","doi":"10.1177/13524585241277018","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Previous studies have suggested differences in multiple sclerosis (MS) severity according to ethnicity.</p><p><strong>Methods: </strong>Data were obtained from the UK MS Register, a prospective longitudinal cohort study of persons with MS. We examined the association between self-reported ethnic background and age at onset, symptom of onset and a variety of participant-reported severity measures. We used adjusted multivariable linear regression models to explore the association between ethnicity and impact of MS, and Cox proportional hazards models to assess disability progression.</p><p><strong>Results: </strong>We analysed data from 17,314 people with MS, including participants from self-reported Black (<i>n</i> = 157) or South Asian (<i>n</i> = 230) ethnic backgrounds. Age at MS onset and diagnosis was lower in those of South Asian (median 30.0) and Black (median 33.0) ethnicity compared with White ethnicity (median 35.0). In participants with online MS severity measures available, we found no statistically significant evidence for an association between ethnic background and physical disability in MS in both cross-sectional and longitudinal analyses.</p><p><strong>Conclusion: </strong>We found no association between ethnic background and MS severity in a large, diverse UK cohort. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":" ","pages":"1544-1555"},"PeriodicalIF":4.8000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520257/pdf/","citationCount":"0","resultStr":"{\"title\":\"The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study.\",\"authors\":\"Benjamin M Jacobs, Luisa Schalk, Emily Tregaskis-Daniels, Pooja Tank, Sadid Hoque, Michelle Peter, Katherine Tuite-Dalton, James Witts, Riley Bove, Ruth Dobson\",\"doi\":\"10.1177/13524585241277018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Previous studies have suggested differences in multiple sclerosis (MS) severity according to ethnicity.</p><p><strong>Methods: </strong>Data were obtained from the UK MS Register, a prospective longitudinal cohort study of persons with MS. We examined the association between self-reported ethnic background and age at onset, symptom of onset and a variety of participant-reported severity measures. We used adjusted multivariable linear regression models to explore the association between ethnicity and impact of MS, and Cox proportional hazards models to assess disability progression.</p><p><strong>Results: </strong>We analysed data from 17,314 people with MS, including participants from self-reported Black (<i>n</i> = 157) or South Asian (<i>n</i> = 230) ethnic backgrounds. Age at MS onset and diagnosis was lower in those of South Asian (median 30.0) and Black (median 33.0) ethnicity compared with White ethnicity (median 35.0). In participants with online MS severity measures available, we found no statistically significant evidence for an association between ethnic background and physical disability in MS in both cross-sectional and longitudinal analyses.</p><p><strong>Conclusion: </strong>We found no association between ethnic background and MS severity in a large, diverse UK cohort. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings.</p>\",\"PeriodicalId\":18874,\"journal\":{\"name\":\"Multiple Sclerosis Journal\",\"volume\":\" \",\"pages\":\"1544-1555\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520257/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple Sclerosis Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/13524585241277018\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13524585241277018","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/20 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:先前的研究表明,多发性硬化症(MS)的严重程度因种族而异:以前的研究表明,多发性硬化症(MS)的严重程度因种族而异:数据来自英国多发性硬化症登记册,这是一项针对多发性硬化症患者的前瞻性纵向队列研究。我们研究了自我报告的种族背景与发病年龄、发病症状和参与者报告的各种严重程度之间的关系。我们使用调整后的多变量线性回归模型来探讨种族与多发性硬化症影响之间的关系,并使用 Cox 比例危险模型来评估残疾进展:我们分析了 17,314 名多发性硬化症患者的数据,其中包括自述为黑人(157 人)或南亚人(230 人)的患者。与白人(中位数 35.0)相比,南亚裔(中位数 30.0)和黑人(中位数 33.0)患者的多发性硬化症发病和诊断年龄较低。在可在线测量多发性硬化症严重程度的参与者中,我们在横向和纵向分析中均未发现种族背景与多发性硬化症身体残疾之间存在统计学意义上的显著关联:我们发现,在一个大型、多样化的英国队列中,种族背景与多发性硬化症严重程度之间没有关联。这些研究结果表明,社会经济地位和结构不平等等其他因素可能解释了之前的研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The relationship between ethnicity and multiple sclerosis characteristics in the United Kingdom: A UK MS Register study.

Background: Previous studies have suggested differences in multiple sclerosis (MS) severity according to ethnicity.

Methods: Data were obtained from the UK MS Register, a prospective longitudinal cohort study of persons with MS. We examined the association between self-reported ethnic background and age at onset, symptom of onset and a variety of participant-reported severity measures. We used adjusted multivariable linear regression models to explore the association between ethnicity and impact of MS, and Cox proportional hazards models to assess disability progression.

Results: We analysed data from 17,314 people with MS, including participants from self-reported Black (n = 157) or South Asian (n = 230) ethnic backgrounds. Age at MS onset and diagnosis was lower in those of South Asian (median 30.0) and Black (median 33.0) ethnicity compared with White ethnicity (median 35.0). In participants with online MS severity measures available, we found no statistically significant evidence for an association between ethnic background and physical disability in MS in both cross-sectional and longitudinal analyses.

Conclusion: We found no association between ethnic background and MS severity in a large, diverse UK cohort. These findings suggest that other factors, such as socioeconomic status and structural inequalities, may explain previous findings.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
期刊最新文献
Cryptogenic organising pneumonia in patients treated with ocrelizumab. Ocrelizumab-associated cryptogenic organizing pneumonia in multiple sclerosis: Two case reports and comprehensive literature review. Vaccination as a risk factor for pediatric multiple sclerosis: Insights from a retrospective case-control study. Secondary organising pneumonia associated to COVID-19 infection in patients with central nervous system inflammatory demyelinating diseases treated with anti-CD20 therapies. Development and initial validation of the Cognitive Change Scale (CCS).
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1