克波克香蕉皮提取物(Musa balbisiana)转移凝胶对 Wistar 大鼠皮肤光老化的改善作用。

IF 0.9 Q3 VETERINARY SCIENCES Open Veterinary Journal Pub Date : 2024-08-01 Epub Date: 2024-08-31 DOI:10.5455/OVJ.2024.v14.i8.28
Elly Mayangsari, Arifa Mustika, Nurdiana Nurdiana, Nozlena Abdul Samad
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引用次数: 0

摘要

背景:反复急性暴露于紫外线 B(UVB)可导致光老化。巴西麝香草果皮含有类黄酮化合物,可作为抗氧化剂。然而,黄酮类化合物的理化性质不稳定,分子量大,容易氧化,导致其用途仍然有限,而且透皮给药的效率不高。目的:研究巴尔比西亚麝香果皮转移体凝胶对 Wistar 大鼠皮肤光老化的改善作用:方法:利用透射电子显微镜(TEM)对转移体凝胶进行表征。采用体内研究来确定 M. balbisiana 果皮的改善效果。转移体凝胶的成分包括巴比妥果皮乙醇提取物、大豆磷脂酰胆碱和吐温 80。该凝胶每周使用三次,连续使用 4 周,紫外线辐射总剂量为 840 mJ/cm2。通过测量皱纹程度、表皮增厚、真皮变薄、胶原纤维不规则、基质金属蛋白酶 1(MMP-1)和转化生长因子-β(TGF-β)表达、丙二醛(MDA)和肿瘤坏死因子-α(TNFα)水平来评估修复机制:TEM结果表明,凝胶转移酶体M. balbisiana果皮具有直径为±50 nm的圆形形态,没有聚集,被定义为纳米颗粒。转运体凝胶通过降低 MDA 和 TNFα 水平抑制脂质过氧化,通过抑制 MMP-1 表达和激活 TGF-β 表达抑制胶原蛋白失衡,从而改善了因紫外线照射引起的皱纹、表皮增厚、真皮变薄和胶原纤维不规则的程度,与非转运体凝胶组相比,差异有统计学意义:结论:M. balbisiana果皮的转移体凝胶可作为一种替代药物,改善因暴露于紫外线而导致的临床光老化。
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Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin.

Background: Repeated acute exposure to ultraviolet B (UVB) rays can cause photoaging. Musa balbisiana peel contains flavonoid compounds which act as antioxidants. However, the physicochemicals of flavonoids are unstable, have high molecular weight, and are easily oxidized, causing their use is still limited and transdermal delivery to be inefficient.

Aim: To investigate the ameliorative effect of transfersome gel of M. balbisiana peels against photoaging in Wistar rat skin.

Methods: Transfersome gel was characterized by transmission electron microscopy (TEM). In vivo research was used to determine the ameliorative effects of M. balbisiana peel. The composition of transfersome consists of ethanol extracts of M. balbisiana peel, soybean phosphatidylcholine, and tween 80. The gel was applied three times a week for 4 weeks with a total UVB radiation dose of 840 mJ/cm2. To evaluate the repair mechanism by measuring the degree of wrinkles, epidermal thickening, dermal thinning, collagen fiber irregularity, matrix metalloproteinase 1 (MMP-1), and transforming growth factor-β (TGF-β) expression, malondialdehyde (MDA) and tumor necrosis factor-α (TNFα) levels.

Results: TEM results show that gel transfersome M. balbisiana peel has a round morphology with a diameter of ±50 nm and no aggregation, which are defined as nanoparticles. Transfersome gel ameliorated the degree of wrinkle, epidermal thickening, dermal thinning, and irregularity of collagen fibers caused by UVB exposure, suppresses lipid peroxidation by decreasing MDA and TNFα level, also collagen imbalance by inhibiting MMP-1 expression and activating TGF-β expression, which was found statistically significantly different from non-transfersome gel group.

Conclusion: Transfersome gel of M. balbisiana peel can act as an alternative medicine to ameliorate clinical photoaging due to exposure to UVB.

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来源期刊
Open Veterinary Journal
Open Veterinary Journal VETERINARY SCIENCES-
CiteScore
1.40
自引率
0.00%
发文量
112
审稿时长
12 weeks
期刊介绍: Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.
期刊最新文献
In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. A rare case of "Hawkins type 3" talar neck fracture in a cat. Ameliorative effect of transfersome gel of kepok banana peel extract (Musa balbisiana) against photoaging in Wistar rat skin. Antimalarial activity of borrelidin and fumagilin in Plasmodium berghei-infected mice. Bovine umbilical mesenchymal stem cell-conditioned medium increased expression of GLUT-4 in pancreas of diabetic rats induced by nicotinamide-streptozotocin.
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