{"title":"度拉鲁肽对老年 2 型糖尿病患者血糖控制和膝关节骨关节炎疼痛的双重影响。","authors":"Shambo Samrat Samajdar, Gaurab Bhaduri, Pradip Kumar Ghoshal, Shatavisa Mukherjee, Jyotirmoy Pal, Nandini Chatterjee, Shashank R Joshi","doi":"10.1080/17581869.2024.2402214","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> This study aims to evaluate the dual benefits of dulaglutide in improving glycemic control and reducing knee OA pain.<b>Patients & methods:</b> Elderly T2DM patients diagnosed with bilateral knee OA on conventional OA treatment for at least 3 months were studied for their glycemic metrics, OA pain scores and NSAID consumption at baseline, 3 months and 6 months.<b>Results:</b> Significant improvements in glycemic control were observed, HbA1c decreased from 8.7% to 6.5% over 6 months. Pain scores, NSAID, body weight and BMI showed substantial reductions over time. Positive correlation (r = 0.73, <i>p</i> < 0.001) was found between glycemic control and pain reduction.<b>Conclusion:</b> Dulaglutide improves glycemic control, knee joint OA pain and weight management in elderly patients with T2DM.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485723/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dual effects of dulaglutide on glycemic control and knee osteoarthritis pain in elderly patients with Type 2 diabetes.\",\"authors\":\"Shambo Samrat Samajdar, Gaurab Bhaduri, Pradip Kumar Ghoshal, Shatavisa Mukherjee, Jyotirmoy Pal, Nandini Chatterjee, Shashank R Joshi\",\"doi\":\"10.1080/17581869.2024.2402214\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> This study aims to evaluate the dual benefits of dulaglutide in improving glycemic control and reducing knee OA pain.<b>Patients & methods:</b> Elderly T2DM patients diagnosed with bilateral knee OA on conventional OA treatment for at least 3 months were studied for their glycemic metrics, OA pain scores and NSAID consumption at baseline, 3 months and 6 months.<b>Results:</b> Significant improvements in glycemic control were observed, HbA1c decreased from 8.7% to 6.5% over 6 months. Pain scores, NSAID, body weight and BMI showed substantial reductions over time. Positive correlation (r = 0.73, <i>p</i> < 0.001) was found between glycemic control and pain reduction.<b>Conclusion:</b> Dulaglutide improves glycemic control, knee joint OA pain and weight management in elderly patients with T2DM.</p>\",\"PeriodicalId\":20000,\"journal\":{\"name\":\"Pain management\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485723/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pain management\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/17581869.2024.2402214\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/20 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pain management","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17581869.2024.2402214","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/20 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：本研究旨在评估度拉鲁肽在改善血糖控制和减轻膝关节OA疼痛方面的双重功效：研究对象： 被诊断为双侧膝关节 OA 的老年 T2DM 患者，接受常规 OA 治疗至少 3 个月，分别在基线、3 个月和 6 个月对其血糖指标、OA 疼痛评分和非甾体抗炎药消耗量进行研究：结果：血糖控制明显改善，6 个月内 HbA1c 从 8.7% 降至 6.5%。随着时间的推移，疼痛评分、非甾体抗炎药、体重和体重指数均大幅下降。正相关性（r = 0.73，p 结论：杜拉鲁肽可改善疼痛评分、非甾体抗炎药、体重和体重指数：度拉鲁肽可改善 T2DM 老年患者的血糖控制、膝关节 OA 疼痛和体重管理。
Dual effects of dulaglutide on glycemic control and knee osteoarthritis pain in elderly patients with Type 2 diabetes.
Aim: This study aims to evaluate the dual benefits of dulaglutide in improving glycemic control and reducing knee OA pain.Patients & methods: Elderly T2DM patients diagnosed with bilateral knee OA on conventional OA treatment for at least 3 months were studied for their glycemic metrics, OA pain scores and NSAID consumption at baseline, 3 months and 6 months.Results: Significant improvements in glycemic control were observed, HbA1c decreased from 8.7% to 6.5% over 6 months. Pain scores, NSAID, body weight and BMI showed substantial reductions over time. Positive correlation (r = 0.73, p < 0.001) was found between glycemic control and pain reduction.Conclusion: Dulaglutide improves glycemic control, knee joint OA pain and weight management in elderly patients with T2DM.
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