一项回顾性研究,评估传统分次放射疗法治疗二十一只犬浸润性脂肪瘤的效果。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2024-12-01 Epub Date: 2024-09-17 DOI:10.1111/vco.13001
Adam Hauser, Lily Thorsen, Mary-Keara Boss, Tiffany W Martin
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引用次数: 0

摘要

浸润性脂肪瘤是脂肪瘤相关肿瘤中较为罕见、可能更具侵袭性的一个亚类。这项回顾性研究共纳入了 21 只接受常规分次放射治疗(CFRT)的浸润性脂肪瘤患犬。其中一名患者之前未接受过手术切除,11 名患者之前接受过一次手术,9 名患者在接受 CFRT 之前接受过两次或两次以上的手术。治疗前,5 名患者(24%)有微小病变,16 名患者(76%)有大面积病变。10名患者(48%)获得完全应答或无再生,6名患者(29%)病情稳定,5名患者(24%)病情进展或再生。曾接受过一次手术和两次或两次以上手术的犬只对治疗大肿瘤的反应有显著差异(p = 0.01)。与接受过两次或两次以上手术并获得完全应答的狗相比,接受过一次手术的狗最有可能获得稳定的病情。未接受手术的狗在211天时病情出现进展,接受一次手术的狗在1369天时病情出现进展或复发,接受两次或两次以上手术的狗在826天时病情出现进展或复发(p = 0.04)。在进行分析时,有 12 只狗仍然存活。总体中位生存时间 (MST) 为 1694 天。之前的手术次数对中位生存时间没有明显影响。虽然存活时间与之前的报告相当,但疾病进展或之前的微小疾病复发的患者人数较多,因此需要对最合适的方案、剂量和治疗区域大小进行更多研究。
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A Retrospective Study Evaluating the Outcomes of Conventionally Fractionated Radiation Therapy as a Treatment for Infiltrative Lipomas in Twenty-One Dogs.

Infiltrative lipomas represent a subcategorisation of rarer, potentially more aggressive, lipoma-related neoplasms. Twenty-one dogs treated with conventionally fractionated radiotherapy (CFRT) for infiltrative lipomas were included in this retrospective study. One patient had no prior surgical excision, 11 patients had one prior surgery and 9 patients had two or more surgeries prior to CFRT. Five patients (24%) had microscopic disease and 16 patients (76%) had macroscopic disease prior to treatment. A complete response or no regrowth was seen in 10 patients (48%), stable disease in 6 patients (29%) and progressive disease or regrowth in 5 patients (24%). Response to treatment of macroscopic tumours was significantly different between dogs that had one prior surgery versus two or more (p = 0.01). Dogs with a single surgery were most likely to result in stable disease compared with dogs with two or more surgeries resulting in a complete response. The dog without surgery developed progressive disease at 211 days, dogs with one surgery had a median progression or recurrence at 1369 days and dogs with two or more surgeries developed progression or recurrence at 826 days (p = 0.04). Twelve dogs were alive at the time of analysis. Overall median survival time (MST) was 1694 days. The prior number of surgeries did not significantly affect MST. While survival time is comparable to previous reports, the number of patients with progressive disease or recurrence of previous microscopic disease requires more investigation into the most appropriate protocol, dose and treated field size.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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