补充辅酶Q10是否能保护环丙沙星诱导的大鼠睾丸的精子发生?

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Clinical and Experimental Reproductive Medicine-CERM Pub Date : 2024-09-20 DOI:10.5653/cerm.2024.07017
Elham Aliabadi, Fateme Amooei, Tahereh Talaei Khozani, Saied Karbalay-Doust, Fatemeh Karimi
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引用次数: 0

摘要

目的:环丙沙星(CPFX生育专科医生和泌尿科医生经常开环丙沙星(CPFX)来治疗男性生殖器官感染。然而,环丙沙星对睾丸有毒性,可导致不育。众所周知,膳食中的抗氧化剂可保护睾丸免受损伤。本研究旨在采用立体学方法研究辅酶Q10(CoQ10)对CPFX不良副作用的影响:将60只大鼠分为6组:对照组(蒸馏水)、辅酶Q10组(10毫克/千克/天)、服用或不服用辅酶Q10的低剂量(103毫克/千克/天)和高剂量(206毫克/千克/天)CPFX组(LD-CPFX、HD-CPFX)。治疗持续 45 天。对精子数量、血清睾酮水平和睾丸参数进行了评估:结果:在 LD-CPFX 试验中观察到精子数量、活力、正常形态、存活率和睾酮水平显著下降(p):暴露于 CPFX 45 天,无论剂量大小,都会对睾丸参数产生不利影响。CoQ10 可预防 CPFX 引起的睾丸结构损伤。
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Does coenzyme Q10 supplementation protect spermatogenesis in ciprofloxacin-induced rat testes?

Objective: Ciprofloxacin (CPFX) is frequently prescribed by fertility specialists and urologists to manage infections in male reproductive organs. However, it is toxic to the testicles and can lead to infertility. Dietary antioxidants are known to protect the testis from damage. This study aimed to investigate the effects of coenzyme Q10 (CoQ10) on the adverse side effects of CPFX using stereological methods.

Methods: Sixty rats were divided into six groups: control (distilled water), CoQ10 (10 mg/kg/day), and low-dose (103 mg/kg/day) and high-dose (206 mg/kg/day) of CPFX (LD-CPFX, HD-CPFX) with or without CoQ10 consumption. The treatments lasted for 45 days. Sperm count, serum testosterone levels, and testicular parameters were evaluated.

Results: Significant decreases in sperm count, motility, normal morphology, viability, and testosterone levels were observed in the LD-CPFX (p<0.003) and HD-CPFX- treated rats (p=0.0001) compared to the control groups. A 10% to 36% reduction in the volume of seminiferous tubules, tubular epithelium, and tubule length was noted in LD-CPFX (p<0.01) and HD-CPFX-treated rats (p<0.006), while the volume of the interstitium increased by 25% to 28% in LD-CPFX (p=0.03) and HD-CPFX (p=0.008) groups. The number of cells, including spermatogonia, spermatocytes, spermatids, Sertoli cells, and Leydig cells, decreased by 36% to 75% in the testes exposed to LD-CPFX (p<0.04) and HD-CPFX (p<0.01), compared to the control groups. However, these changes normalized in rats that received CoQ10.

Conclusion: CPFX exposure for 45 days, regardless of the dose, has detrimental effects on testicular parameters. CoQ10 can prevent CPFX-induced testicular structural impairments.

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Does coenzyme Q10 supplementation protect spermatogenesis in ciprofloxacin-induced rat testes? Pathological and vascular changes in the rat testiсle after experimental trauma. State-of-the-art in high throughput organ-on-chip for biotechnology and pharmaceuticals. In vivo and in vitro sperm production: an overview of the challenges and advances in male fertility restoration. Outcomes of female reproductive performance with assisted reproductive techniques after recent mild to moderate COVID-19 infections: An observational study.
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