血清白细胞介素-7、白细胞介素-15 和乳酸盐之间的相关性分析有助于了解它们在老年败血症患者炎症调节中的潜在作用。

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Insights Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI:10.1177/11772719241275525
Jingjing Zhao, Ye Zhang, Jun-Yu Wang, Bing Wei, Yu-Geng Liu
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引用次数: 0

摘要

背景:我们之前的研究发现白细胞介素(IL)-7和IL-15是老年脓毒症患者的预后生物标志物,然而,人们对老年脓毒症患者血清中IL-7、IL-15和乳酸盐水平之间的联系以及它们在炎症调节中的潜在作用知之甚少:本研究旨在探讨老年脓毒症患者血清中 IL-7、IL-15 和乳酸盐水平之间的联系以及与其他因素的关系:这是一项回顾性研究,共纳入 129 名老年脓毒症患者,分为存活组(34 人)和非存活组(95 人),并根据急性生理学和慢性健康评估 II(APACHE II)评分进一步分组:入院后 24 小时内记录基线数据和临床参数。采用 Luminex 检测法对血清中的细胞因子水平进行量化。结果结果:非存活组的血清中 IL-6、IL-7、IL-15 和肿瘤坏死因子-α(TNF-α)的水平显著高于存活组(P P P 结论:血清中细胞因子之间的调控网络是影响存活组的重要因素:了解血清中IL-7、IL-15、乳酸和其他细胞因子水平之间的调控网络,有助于了解老年脓毒症患者炎症调节的潜在机制,并促进更及时、准确的治疗,降低死亡率。
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Correlation Analyses Between Serum Interleukin-7, Interleukin-15 and Lactate Provide Insights Into Their Potential Roles in the Regulation of Inflammation in Elderly Septic Patients.

Background: Our previous research have identified Interleukin (IL)-7 and IL-15 as prognostic biomarkers for elderly septic patients, however, little is known about the link between the serum levels of IL-7, IL-15, and lactate as well as their potential roles in the regulation of inflammation in elderly septic patients.

Objectives: This study aimed at investigating the link between the serum levels of IL-7, IL-15, and lactate as well as with other factors in elderly septic patients.

Design: This is a retrospective study including 129 elderly patients with sepsis who were divided into the survival group (N = 34) and the nonsurvival group (N = 95) and further subgrouped based on the Acute Physiology and Chronic Health Evaluation II (APACHE II) scores.

Methods: The baseline data and clinical parameters were recorded within 24 h upon admission. Serum levels of the cytokines were quantified by the Luminex assay. Spearman correlation analysis were performed.

Results: Serum levels of IL-6, IL-7, IL-15, and tumor necrosis factor-α (TNF-α) were significantly higher in the nonsurvival group (P < .05). Correlations between serum levels of IL-7 and platelet-derived growth factor-AA (PDGF-AA), as well as correlations between IL-15, IL-6, and TNF-α were confirmed (P < .05). Both the serum levels of lactate and IL-15 correlated with the total counts of platelet (PLT) in the survival subgroup with low APACHE Ⅱ scores while the serum levels of IL-7, IL-15, and total counts of monocytes correlated with each other in the nonsurvival subgroup with different APACHE Ⅱ scores (P < .05).

Conclusion: Knowledge of the regulation networks between serum levels of IL-7, IL-15, lactate, and other cytokines may provide insights into potential mechanisms in the modulation of inflammation in elderly septic patients and facilitate more prompt and accurate treatment to reduce the mortality rate.

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来源期刊
Biomarker Insights
Biomarker Insights MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.00
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
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