男性冠状动脉粥样硬化斑块中的脂肪组织生物大分子

IF 0.5 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Kardiologiya Pub Date : 2024-08-31 DOI:10.18087/cardio.2024.8.n2634
E V Garbuzova, Ya V Polonskaya, E V Kashtanova, E M Stakhneva, V S Shramko, I S Murashov, A V Kurguzov, A M Chernyavsky, Yu I Ragino
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引用次数: 0

摘要

目的:研究冠状动脉粥样硬化男性患者动脉粥样硬化斑块(AP)中脂肪组织的代谢分子(脂肪连素、脂肪素、抵抗素、胰高血糖素样肽-1(GLP-1)、胰高血糖素、胰泌素)及其与动脉粥样硬化斑块不稳定性的关系:脂肪组织的代谢分子(脂肪细胞因子和代谢激素)可作为酶、激素或生长因子调节胰岛素抵抗、脂质和葡萄糖代谢,并间接影响动脉粥样硬化过程。这项研究包括 48 名男性,在获得知情同意后,收集了他们在冠状动脉搭桥术期间的 139 个冠状动脉(CA)样本。根据组织学结论,84 个(60.4%)冠状动脉斑块是稳定的,44 个(31.7%)是不稳定的,11 个组织学样本的冠状动脉内膜有条件性变化(7.9%)。通过使用人类代谢激素 V3 面板(德国 MILLIPLEX 公司)进行多重分析,测量了 AP 匀浆中的脂肪连素、脂肪素、抵抗素、GLP-1、胰高血糖素和胰泌素的浓度。研究期间记录了人口统计学和人体测量特征、病史和是否患有慢性疾病:结果:与稳定的动脉粥样硬化斑块碎片相比,条件不变的内膜中的胰高血糖素浓度低 16.7%,不稳定的动脉粥样硬化斑块碎片中的胰高血糖素浓度低 41.2%。然而,稳定 AP 中的胰高血糖素浓度比不稳定 AP 高 28%。在条件不变的内膜中,胰泌素浓度也比稳定型 AP 低 41.2%,而在稳定型 AP 中,胰泌素浓度比不稳定型 AP 高 20%。脂联素浓度与血清高密度脂蛋白胆固醇(HDL-C)浓度直接相关(r=0.286;p=0.002),而分泌素浓度与血清高密度脂蛋白胆固醇浓度成反比(r=-0.199;p=0.038)。当 AP 胰高血糖素浓度增加 1 pg/mg 蛋白时,出现不稳定 AP(与条件不变的内膜有关)的概率增加 35.8%。AP胰高血糖素浓度增加1 pg/mg蛋白,出现稳定AP(相对于未改变的内膜)的概率增加29.4%;AP胰泌素浓度增加1 pg/mg蛋白,出现稳定AP的概率增加10.1%:结论:胰高血糖素浓度与血清高密度脂蛋白胆固醇浓度直接相关,而胰高血糖素浓度与血清高密度脂蛋白胆固醇浓度成反比。在冠状动脉粥样硬化男性患者中,稳定和不稳定AP的存在与AP胰高血糖素浓度直接相关。在冠状动脉粥样硬化男性患者中,AP 分泌素浓度与斑块稳定性直接相关。对动脉粥样硬化病变中已确定的标记物进行进一步深入研究,可将其作为潜在的治疗目标。
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Biomolecules of Adipose Tissue in Atherosclerotic Plaques of Men With Coronary Atherosclerosis.

Aim: To study metabolic molecules (adiponectin, adipsin, resistin, glucagon-like peptide-1 (GLP-1), glucagon, secretin) of adipose tissue in atherosclerotic plaques (AP) and their associations with AP instability in men with coronary atherosclerosis.

Material and methods: Metabolic molecules (adipocytokines and metabolic hormones) of adipose tissue can act as enzymes, hormones or growth factors in modulating insulin resistance and lipid and glucose metabolism and indirectly influence the course of the atherosclerotic process. This study included 48 men from whom 139 coronary artery (CA) samples were collected during coronary artery bypass grafting, after obtaining the informed consent. According to the histological conclusion, 84 (60.4%) CA plaques were stable, 44 (31.7%) were unstable, and 11 histological samples had a conditionally unchanged CA intima (7.9%). The concentrations of adiponectin, adipsin, resistin, GLP-1, glucagon, and secretin were measured in AP homogenates by multiplex analysis using the Human Metabolic Hormone V3 panel (MILLIPLEX, Germany). During the study, demographic and anthropometric characteristics, medical history, and presence of chronic diseases were recorded.

Results: The glucagon concentration in the conditionally unchanged intima was 16.7% lower and in the fragments of unstable atherosclerotic plaques 41.2% lower than in fragments of stable APs. However, the glucagon concentration in stable APs was 28% higher than in unstable APs. The secretin concentration in the conditionally unchanged intima was also lower than in stable APs by 41.2%, while in stable APs, the secretin concentration was 20% higher than in unstable APs. The adiponectin concentrations were directly correlated with serum high-density lipoprotein cholesterol (HDL-C) concentrations (r=0.286; p=0.002), while the secretin concentrations were inversely correlated with serum HDL-C concentrations (r= -0.199; p=0.038). The probability of having an unstable AP (in relation to conditionally unchanged intima) increases by 35.8% with an increase in the AP glucagon concentration by 1 pg/mg protein. The probability of having a stable AP (in relation to unchanged intima) increases by 29.4% with an increase in the AP glucagon concentration by 1 pg/mg protein and by 10.1% with an increase in the AP secretin concentration by 1 pg/mg protein.

Conclusion: The AP adiponectin concentration directly correlates and the AP secretin concentration inversely correlates with the serum concentration of HDL-C. The presence of both stable and unstable APs is directly associated with the AP glucagon concentration in men with coronary atherosclerosis. The AP secretin concentration is directly associated with plaque stability in men with coronary atherosclerosis. Further thorough study of the identified markers in atherosclerotic lesions will allow using them as potential targets for therapy.

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来源期刊
Kardiologiya
Kardiologiya 医学-心血管系统
CiteScore
1.70
自引率
20.00%
发文量
94
审稿时长
3-8 weeks
期刊介绍: “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.
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