利用选择基因驱动克服耐药性肿瘤。

IF 11.1 Q1 CELL BIOLOGY Cell genomics Pub Date : 2024-09-11 DOI:10.1016/j.xgen.2024.100653
Hui Wang, Mingqi Xie
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引用次数: 0

摘要

耐药性是阻碍包括癌症在内的许多疾病有效治疗的主要障碍。Leighow 等人1 利用模型指导设计,设计了一种双开关选择基因驱动系统,专门用于对抗耐药性肿瘤。通过在体外和小鼠体内使用人类非小肺癌细胞的临床前模型中展示出显著的杀伤效果,这项工作描述了一种开发下一代抗癌疗法的诱人思路。
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Overcoming drug-resistant tumors with selection gene drives.

Drug resistance is a major hurdle prohibiting effective treatment of many diseases, including cancer. Using model-guided designs, Leighow et al.1 engineered a dual-switch selection gene drive system custom designed to combat drug-resistant tumors. By demonstrating remarkable killing efficacies in preclinical models using human non-small lung cancer cells in vitro and in mice, this work describes an attractive mindset to develop next-generation anticancer therapies.

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