利用液相色谱-四极杆-轨道阱高分辨质谱法测定牛肝、牛肉、牛心和牛肾中的齐帕特罗。

IF 2.5 3区农林科学 Q2 CHEMISTRY, APPLIED Food additives & contaminants. Part B, Surveillance Pub Date : 2024-09-24 DOI:10.1080/19393210.2024.2405609

Omar Khaled, Lamia Ryad, Nermine Gad, Fawzy Eissa

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引用次数: 0

摘要

采用液相色谱-四极杆-轨道阱高分辨质谱（LC-Q-Orbitrap HRMS）技术，建立了牛肝、牛肉、牛心和牛肾中齐帕特罗的鉴定和定量分析方法。根据欧盟委员会实施条例（CIR）EU 2021/808，在 0.1 至 5 μg/kg 六种不同浓度下对该方法进行了验证。平均回收率为71%～99%，检出限（CCα）和检出限（CCβ）分别为0.11～0.12 μg/kg和0.13～0.15 μg/kg。该方法的线性关系良好（R2 > 0.9996），检出限（LOD）和定量限（LOQ）分别为 0.015-0.061 μg/kg 和 0.025-0.091 μg/kg。在埃及当地市场采集的 200 个样本中，有 17 个样本含有齐帕特罗残留物。肝脏样本的检测频率最高（26%），其次是肉类（6%），平均浓度分别为 2.64 和 1.93 μg/kg。

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Zilpaterol in bovine liver, meat, heart, and kidney, determined by liquid chromatography-quadrupole-orbitrap high-resolution mass spectrometry.

An analytical method was developed for identification and quantification of zilpaterol in bovine liver, meat, heart, and kidney, using liquid chromatography coupled to quadrupole-Orbitrap high-resolution mass spectrometry (LC-Q-Orbitrap HRMS). It was validated in accordance with Commission Implementing Regulation (CIR) EU 2021/808 at six different concentrations, ranging from 0.1 to 5 μg/kg. The mean recoveries ranged from 71% to 99%, while the decision limit (CCα) and detection capability (CCβ) ranges were 0.11-0.12 μg/kg and 0.13-0.15 μg/kg, respectively. The method demonstrated good linearity (R² > 0.9996) and the limits of detection (LODs) and of quantification (LOQs) were in the range of 0.015-0.061 μg/kg and 0.025-0.091 μg/kg, respectively. Out of 200 samples collected from local markets in Egypt, 17 contained zilpaterol residues. Liver samples revealed the highest detection frequency (26%), followed by meat (6%), at mean concentrations of 2.64 and 1.93 μg/kg, respectively.

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来源期刊

Food additives & contaminants. Part B, Surveillance 农林科学-毒理学

CiteScore

5.30

自引率

10.30%

发文量

审稿时长

2.7 months

期刊介绍： Food Additives & Contaminants: Part B publishes surveillance data indicating the presence and levels of occurrence of designated food additives, residues and contaminants in foods, food supplements and animal feed. Data using validated methods must meet stipulated quality standards to be acceptable and must be presented in a prescribed format for subsequent data-handling. Food Additives & Contaminants: Part B restricts its scope to include certain classes of food additives, residues and contaminants. This is based on a goal of covering those areas where there is a need to record surveillance data for the purposes of exposure and risk assessment. The scope is initially restricted to: Additives - food colours, artificial sweeteners, and preservatives; Residues – veterinary drug and pesticide residues; Contaminants – metals, mycotoxins, phycotoxins, plant toxins, nitrate/nitrite, PCDDs/PCFDs, PCBs, PAHs, acrylamide, 3-MPCD and contaminants derived from food packaging. Readership: The readership includes scientists involved in all aspects of food safety and quality and particularly those involved in monitoring human exposure to chemicals from the diet. Papers reporting surveillance data in areas other than the above should be submitted to Part A . The scope of Part B will be expanded from time-to-time to ensure inclusion of new areas of concern.

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