利用全脑三维磁共振光谱和回声平面时间分辨成像对胶质瘤患者和健康人的代谢物进行绝对定量。

IF 12.1 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiology Pub Date : 2024-09-01 DOI:10.1148/radiol.232401
Mehran Baboli, Fuyixue Wang, Zijing Dong, Jorg Dietrich, Erik J Uhlmann, Tracy T Batchelor, Daniel P Cahill, Ovidiu C Andronesi
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引用次数: 0

摘要

背景:目的:结合全脑 MRSI 和回声平面时间分辨成像(EPTI)弛豫测量法,为胶质瘤患者和健康人的代谢物浓度开发一种快速绝对量化方法:在这项于 2022 年 8 月至 2023 年 8 月进行的前瞻性研究中,以体内水为浓度参考,将 MRSI-EPTI 定量方法与使用人群平均文献弛豫值的传统方法进行了比较。健康参试者和患有突变 IDH1 胶质瘤的参试者使用 32 通道线圈在 3 T 下进行了成像。实时导航绝热螺旋三维 MRSI 扫描在大约 8 分钟内完成,并通过超分辨率管道重建,获得了 2.4 毫米各向同性分辨率的脑代谢图像。高空间分辨率多参数 EPTI 在 3 分钟内完成,各向同性分辨率为 1 毫米,用于校正水参考信号的弛豫和质子密度。使用Bland-Altman分析和Wilcoxon符号秩检验来比较建议方法和传统方法的绝对定量结果:共纳入六名健康参与者(四名男性;平均年龄为 37 岁 ± 11 [SD])和九名胶质瘤患者(六名男性;平均年龄为 41 岁 ± 15;一名为野生型 IDH1,八名为突变型 IDH1)。在健康参试者中,两种方法得出的代谢浓度具有良好的一致性(+4% 偏差),CI 为正负 26%。在患有胶质瘤的参试者中,两种方法之间的差异较大(偏差+39%),CI 为正负 55%。拟议的量化方法提高了总 N-乙酰天冬氨酸(EPTI:0.541 [95% CI:0.217, 0.910];常规:0.484 [95% CI:0.199, 0.823])、总胆碱(EPTI:1.053[95%CI:0.681,1.713];常规:0.940[95%CI:0.617,1.295])和总肌酸(EPTI:0.745[95%CI:0.628,0.909];常规:0.553[95%CI:0.444,0.828])(P = .03):结论:全脑 MRSI-EPTI 方法在 2.4 毫米各向同性分辨率下对代谢浓度进行了快速绝对量化和个体特异性校正,与传统的基于文献的校正方法相比,该方法得出的代谢浓度更接近疾病的真实值。RSNA, 2024 这篇文章有补充材料。
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Absolute Metabolite Quantification in Individuals with Glioma and Healthy Individuals Using Whole-Brain Three-dimensional MR Spectroscopic and Echo-planar Time-resolved Imaging.

Background: MR spectroscopic imaging (MRSI) can be used to quantify an extended brain metabolic profile but is confounded by changes in tissue water levels due to disease.

Purpose: To develop a fast absolute quantification method for metabolite concentrations combining whole-brain MRSI with echo-planar time-resolved imaging (EPTI) relaxometry in individuals with glioma and healthy individuals.

Materials and methods: In this prospective study performed from August 2022 to August 2023, using internal water as concentration reference, the MRSI-EPTI quantification method was compared with the conventional method using population-average literature relaxation values. Healthy participants and participants with mutant IDH1 gliomas underwent imaging at 3 T with a 32-channel coil. Real-time navigated adiabatic spiral three-dimensional MRSI scans were acquired in approximately 8 minutes and reconstructed with a super-resolution pipeline to obtain brain metabolic images at 2.4-mm isotropic resolution. High-spatial-resolution multiparametric EPTI was performed in 3 minutes, with 1-mm isotropic resolution, to correct the relaxation and proton density of the water reference signal. Bland-Altman analysis and the Wilcoxon signed rank test were used to compare absolute quantifications from the proposed and conventional methods.

Results: Six healthy participants (four male; mean age, 37 years ± 11 [SD]) and nine participants with glioma (six male; mean age, 41 years ± 15; one with wild-type IDH1 and eight with mutant IDH1) were included. In healthy participants, there was good agreement (+4% bias) between metabolic concentrations derived using the two methods, with a CI of plus or minus 26%. In participants with glioma, there was large disagreement between the two methods (+39% bias) and a CI of plus or minus 55%. The proposed quantification method improved tumor contrast-to-noise ratio (median values) for total N-acetyl-aspartate (EPTI: 0.541 [95% CI: 0.217, 0.910]; conventional: 0.484 [95% CI: 0.199, 0.823]), total choline (EPTI: 1.053 [95% CI: 0.681, 1.713]; conventional: 0.940 [95% CI: 0.617, 1.295]), and total creatine (EPTI: 0.745 [95% CI: 0.628, 0.909]; conventional: 0.553 [95% CI: 0.444, 0.828]) (P = .03 for all).

Conclusion: The whole-brain MRSI-EPTI method provided fast absolute quantification of metabolic concentrations with individual-specific corrections at 2.4-mm isotropic resolution, yielding concentrations closer to the true value in disease than the conventional literature-based corrections. © RSNA, 2024 Supplemental material is available for this article.

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来源期刊
Radiology
Radiology 医学-核医学
CiteScore
35.20
自引率
3.00%
发文量
596
审稿时长
3.6 months
期刊介绍: Published regularly since 1923 by the Radiological Society of North America (RSNA), Radiology has long been recognized as the authoritative reference for the most current, clinically relevant and highest quality research in the field of radiology. Each month the journal publishes approximately 240 pages of peer-reviewed original research, authoritative reviews, well-balanced commentary on significant articles, and expert opinion on new techniques and technologies. Radiology publishes cutting edge and impactful imaging research articles in radiology and medical imaging in order to help improve human health.
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