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Contrast-Enhanced US Using Perfluorobutane for Diagnosing Small HCC in High-Risk Patients: Comparison with MRI LI-RADS Version 2018. 全氟丁烷造影增强超声诊断高危患者小肝癌:与MRI LI-RADS 2018版的比较
IF 19.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.252271
Yu Li,Shilin Lu,Siyue Mao,Qing Li,Xuebin Zou,Sheng Li,Xiaoxian Li,Dan Lu,Min Xu,Hui-Xiong Xu,Tian'An Jiang,Andrej Lyshchik,Lingling Li,Jianhua Zhou
Background Evidence supporting the incorporation of perfluorobutane (PFB) contrast-enhanced US (CEUS) into Liver Imaging Reporting and Data System (LI-RADS) in diagnosing small hepatocellular carcinoma (HCC) (≤20 mm) in patients at high risk for HCC remains limited. Purpose To compare diagnostic performance of PFB CEUS and MRI for small HCC in high-risk patients. Materials and Methods This multicenter retrospective study included high-risk patients who underwent PFB CEUS and concurrent MRI for evaluating liver nodules 20 mm or smaller from March 2020 to November 2023. PFB CEUS strategy A followed LR-5 criteria based on CEUS LI-RADS version 2017: observations that were at least 10 mm with nonrim arterial-phase hyperenhancement (APHE), with late and mild washout assessed up to 5 minutes postinjection; strategy B expanded on strategy A by also incorporating observations 10 mm or larger with nonrim APHE, no washout up to 5 minutes, and hypoenhancement on Kupffer-phase images. The diagnostic performance of these two CEUS strategies and MRI LI-RADS version 2018 was compared using a generalized estimating equations approach. Results A total of 365 patients (median age, 54 years; IQR, 47-61 years; 310 men) with 399 observations (median diameter, 16 mm; IQR, 12-19 mm; 252 HCCs, 41 non-HCC malignancies, 106 benign nodules) were included. Strategy B yielded higher sensitivity than strategy A (65.9% [166 of 252] vs 57.1% [144 of 252]; P < .001) without evidence of a decrease in specificity (91.8% [135 of 147] vs 93.9% [138 of 147]; P = .07). Compared with MRI, strategy B showed no evidence of a difference in sensitivity (65.9% [166 of 252] vs 72.6% [183 of 252]; P = .07) and specificity (91.8% [135 of 147] vs 90.5% [133 of 147]; P = .59). Strategies A and B showed higher specificity (97.4% [76 of 78] vs 89.9% [62 of 69]; 96.2% [75 of 78] vs 87.0% [60 of 69], respectively; both P = .04) but no evidence of a difference in sensitivity (54.8% [46 of 84] vs 58.3% [98 of 168] [P = .63]; 61.9% [52 of 84] vs 67.9% [114 of 168] [P = .39], respectively) in patients without cirrhosis versus in patients with cirrhosis. Conclusion In patients at high risk for HCC, PFB CEUS incorporating Kupffer-phase findings was effective for diagnosing small HCC, with diagnostic performance similar to MRI. © RSNA, 2026 Supplemental material is available for this article.
背景:支持将全氟丁烷(PFB)增强超声造影(CEUS)纳入肝成像报告和数据系统(LI-RADS)诊断肝癌高危患者小肝细胞癌(HCC)(≤20 mm)的证据仍然有限。目的比较PFB超声造影与MRI对高危小肝癌的诊断价值。材料和方法本多中心回顾性研究纳入了2020年3月至2023年11月期间接受PFB超声造影和同期MRI检查20mm或更小肝结节的高危患者。PFB超声造影策略A遵循基于2017年版超声造影LI-RADS的LR-5标准:观察到非边缘动脉期高增强(APHE)至少10毫米,注射后5分钟评估晚期和轻度冲洗;策略B在策略A的基础上进行了扩展,还采用了10mm或更大的非边缘APHE观测,5分钟内无冲洗,以及库普弗相图像的低增强。使用广义估计方程方法比较这两种超声造影策略和MRI LI-RADS版本2018的诊断性能。结果共纳入365例患者(中位年龄54岁;IQR 47-61岁;男性310例),399例观察(中位直径16 mm; IQR 12-19 mm; 252例hcc, 41例非hcc恶性肿瘤,106例良性结节)。策略B的敏感性高于策略A (65.9% [166 / 252] vs 57.1% [144 / 252]; P < 0.001),但没有证据表明特异性降低(91.8% [135 / 147]vs 93.9% [138 / 147]; P = 0.07)。与MRI相比,B策略在敏感性(65.9% [166 / 252]vs 72.6% [183 / 252], P = 0.07)和特异性(91.8% [135 / 147]vs 90.5% [133 / 147], P = 0.59)方面无差异。策略A和B在无肝硬化患者和肝硬化患者中表现出更高的特异性(分别为97.4%[78 / 76]和89.9%[69 / 62];分别为96.2%[78 / 75]和87.0%[69 / 60];均P = 0.04),但没有证据表明敏感性差异(分别为54.8%[84 / 46]和58.3% [98 / 168][P = 0.63]; 61.9%[84 / 52]和67.9% [114 / 168][P = 0.39])。结论在HCC高危患者中,PFB超声合并Kupffer-phase表现可有效诊断小肝癌,其诊断性能与MRI相似。©RSNA, 2026本文提供补充材料。
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引用次数: 0
J-Editing Proton MR Spectroscopy for Brain Signal Separation in Methylmalonic Acidemia: A Pediatric Case-Control Study. j编辑质子磁共振光谱用于甲基丙二酸血症的脑信号分离:一项儿科病例对照研究。
IF 19.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.251117
Mengyuan Zhuo,Yan Yun,Jiaxiang Xin,Aocai Yang,Yufan Chen,Yang Zhao,Guangbin Wang
Background Methylmalonic acid (MMA) accumulates due to mitochondrial dysfunction or enzymatic deficiencies. Methylmalonic acidemia causes central nervous system damage. In vivo detection of MMA using conventional proton (1H) MR spectroscopy is hindered by overlap with lactate and lipids at 1.33 ppm. Purpose To evaluate the feasibility of an optimized J-editing 1H MR spectroscopy protocol to selectively detect MMA and lactate signals in both phantoms and individuals with methylmalonic acidemia. Materials and Methods In this prospective pediatric case-control study, individuals with genetically confirmed methylmalonic acidemia and age-matched control participants underwent brain J-editing 1H MR spectroscopy. The primary endpoint was the feasibility of selective in vivo detection of cerebral MMA using J-editing 1H MR spectroscopy. Phantoms were prepared with different MMA to lactate ratios. Correlations between cerebral MMA signals and biochemical markers (blood propionylcarnitine to acetylcarnitine [C3/C2] ratio and urinary MMA levels) were assessed using Spearman correlation in individuals diagnosed with methylmalonic acidemia. The diagnostic performance of MR spectroscopy and urinary MMA measurement was evaluated against genetic confirmation with use of sensitivity, specificity, and receiver operating characteristic curves. Results A total of 42 participants were included: 24 with methylmalonic acidemia (mean age, 8.7 years ± 5.2 [SD]) and 18 control participants (mean age, 8.9 years ± 4.0 [SD]). The J-editing 1H MR spectroscopy protocol effectively separated MMA and lactate signals in the brains of individuals with methylmalonic acidemia, consistent with phantom results. No abnormal MMA peaks were observed in control participants. The intensity of cerebral MMA signals correlated with blood C3/C2 ratio (Spearman ρ = 0.53 [95% CI: 0.15, 0.78]; P = .008) and urinary MMA levels (ρ = 0.66 [95% CI: 0.33, 0.84]; P < .001). Conclusion J-editing 1H MR spectroscopy reliably and noninvasively detected cerebral MMA in vivo, distinguishing it from overlapping lactate signals. © RSNA, 2026 Supplemental material is available for this article.
背景甲基丙二酸(MMA)由于线粒体功能障碍或酶缺陷而积累。甲基丙二酸血症会导致中枢神经系统损伤。在体内使用常规质子(1H)磁共振光谱检测MMA受到1.33 ppm与乳酸和脂类重叠的阻碍。目的评价一种优化的j -编辑1H MR光谱方案在甲基丙二酸血症患者和幻影患者中选择性检测MMA和乳酸信号的可行性。材料和方法在这项前瞻性儿科病例对照研究中,遗传确诊的甲基丙二酸血症患者和年龄匹配的对照组接受了脑j -编辑1H磁共振波谱检查。主要终点是使用j -编辑1H磁共振光谱在体内选择性检测脑MMA的可行性。以不同的MMA与乳酸的比例制备模型。在诊断为甲基丙二酸血症的个体中,使用Spearman相关性评估脑MMA信号与生化标志物(血丙酰肉碱与乙酰肉碱[C3/C2]比值和尿MMA水平)之间的相关性。磁共振光谱和尿MMA测量的诊断性能通过使用敏感性、特异性和受体工作特征曲线与遗传确认进行评估。结果共纳入42例受试者:甲基丙二酸血症患者24例(平均年龄8.7岁±5.2 [SD]),对照组18例(平均年龄8.9岁±4.0 [SD])。j -编辑1H MR光谱方案有效地分离了甲基丙二酸血症个体大脑中的MMA和乳酸信号,与幻影结果一致。对照组未见异常MMA峰。脑MMA信号强度与血C3/C2比值(Spearman ρ = 0.53 [95% CI: 0.15, 0.78]; P = 0.008)和尿MMA水平(ρ = 0.66 [95% CI: 0.33, 0.84]; P < 0.001)相关。结论j -编辑1H磁共振谱技术可靠、无创地检测了体内脑MMA,并将其与重叠的乳酸信号区分开来。©RSNA, 2026本文提供补充材料。
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引用次数: 0
How I Do It: Fast MRI of the Joints. 怎么做:关节的快速核磁共振成像。
IF 15.2 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.251430
Jan Vosshenrich, Jan Fritz

This article provides a practice-oriented overview of current concepts in rapid musculoskeletal MRI of central and peripheral joints, focusing on echo train optimization and the application of modern acceleration techniques. Parallel imaging, simultaneous multislice acquisition, and compressed sensing-based undersampling can be applied independently or in combination to expedite MRI of the joints. Clinically available three- to eightfold acceleration of two-dimensional (2D) and three-dimensional turbo spin-echo (TSE) pulse sequences enables comprehensive 5-10-minute MRI protocols of joints. This acceleration allows for the efficient integration of advanced metal artifact reduction techniques into clinical MRI protocols. When conventional image reconstruction techniques fail, clinically available deep learning-based image reconstruction and superresolution augmentation methods effectively reconstruct images from highly accelerated acquisitions. Together, moderate acceleration and advanced image reconstruction techniques provide high diagnostic image quality of heavily undersampled MRI data, enabling three- to sixfold accelerated 2D TSE MRI of multiple joints in 4-6 minutes. Recent studies indicate that specially designed and trained deep learning methods may achieve 10-fold accelerated musculoskeletal MRI, with acquisition times under 3 minutes. Although further research and data are necessary, these promising developments are poised to enhance the value of musculoskeletal MRI.

本文以实践为导向概述了中央和外周关节快速肌肉骨骼MRI的当前概念,重点是回声序列优化和现代加速技术的应用。并行成像、同步多层采集和基于压缩感知的欠采样可以单独或联合应用,以加快关节的MRI。临床上可用的二维(2D)和三维涡轮自旋回波(TSE)脉冲序列的三到八倍加速度,可以实现关节的全面5-10分钟MRI协议。这种加速允许将先进的金属伪影减少技术有效地集成到临床MRI协议中。当传统的图像重建技术失败时,临床可用的基于深度学习的图像重建和超分辨率增强方法可以有效地从高度加速的采集中重建图像。适度加速和先进的图像重建技术共同为严重欠采样的MRI数据提供了高诊断图像质量,使多个关节的2D TSE MRI在4-6分钟内加速三到六倍。最近的研究表明,专门设计和训练的深度学习方法可以实现10倍的肌肉骨骼MRI加速,获取时间在3分钟以下。虽然还需要进一步的研究和数据,但这些有希望的发展有望提高肌肉骨骼MRI的价值。
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引用次数: 0
Mature Cystic Teratoma of the Bile Duct. 胆管成熟囊性畸胎瘤。
IF 15.2 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.252350
Yong Cai, Shun Yu
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引用次数: 0
Potassium MRI at 7 T: Opening a Window into Intracellular Electrolyte Balance. 7 T钾核磁共振成像:打开细胞内电解质平衡的窗口。
IF 19.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.260486
Jutta Ellermann
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引用次数: 0
Ablation of Liver Malignancies Is Safe: Does This Fully Define Its Role? 肝恶性肿瘤消融是安全的:这是否完全定义了它的作用?
IF 15.2 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.260546
Michael A Bettmann
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引用次数: 0
Revised Criterion for Identifying Small-Bowel Stricture in Crohn Disease at CT Enterography. 克罗恩病CT肠造影诊断小肠狭窄的修订标准。
IF 15.2 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.253113
Se Jin Choi, Eun Sun Choi, Hae Young Kim, Seonok Kim, Jong Keon Jang, Yong Sik Yoon, Byong Duk Ye, Seong Ho Park

Background Recent guidelines lowered the prestenotic dilatation threshold from >3 cm to ≥2.5 cm for diagnosing small-bowel stricture at CT enterography (CTE) in Crohn disease (CD). Its impact on stricture prevalence and risk stratification is unknown. Purpose To quantify the increase in stricture prevalence when applying a threshold of ≥2.5 cm and to assess whether risks for adverse outcomes are stratified according to the new threshold. Materials and Methods This retrospective study included patients with CD without acute obstructive symptoms who underwent CTE from 2017 to 2018 for routine follow-up of CD. Patients were classified into three groups: nonstricture, stricture with a prestenotic dilatation of 2.5-3 cm, and stricture with a dilatation of >3 cm. Stricture prevalence was calculated using both conventional and revised thresholds. Clinical outcomes during follow-up were analyzed using a Cox proportional hazards regression and Poisson regression, adjusting for relevant covariates. Results Among 1022 patients (median age, 35 years [IQR, 28-42 years]; 719 [70.4%] men), 190 (18.6%) had strictures with a prestenotic dilatation of >3 cm, and 137 (13.4%) had strictures with a prestenotic dilatation of 2.5-3 cm-a prevalence of 32.0% (327 of 1022 patients) using the new threshold. Compared with the nonstricture group, both stricture groups-2.5-3 cm and >3 cm-had a higher risk for emergency department visits (adjusted hazard ratios [HRs], 2.13 [P < .001] and 2.04 [P < .001], respectively; incidence rate ratio, 2.46 [P < .001] and 2.05 [P = .002]), small-bowel surgery (adjusted HRs, 2.27 [P = .006] and 3.58 [P < .001]), symptomatic obstruction (adjusted HRs, 7.99 [P < .001] and 6.25 [P < .001]), and small-bowel penetration (ie, de novo occurrence or progression of a sinus or fistula to an abscess or inflammatory mass) (adjusted HRs, 3.47 [P < .001] and 4.41 [P < .001]). Conclusion Applying a prestenotic dilatation threshold of ≥2.5 cm at CTE enabled identification of small-bowel strictures in additional patients with CD without acute obstructive symptoms, and these patients had increased risks of adverse clinical outcomes. © RSNA, 2026 Supplemental material is available for this article.

近期指南将克罗恩病(CD) CT肠造影(CTE)诊断小肠狭窄时的狭窄扩张阈值从30cm降低到≥2.5 cm。其对狭窄患病率和风险分层的影响尚不清楚。目的:量化应用≥2.5 cm阈值时狭窄患病率的增加,并评估不良结局的风险是否根据新的阈值进行分层。材料与方法本回顾性研究纳入2017 - 2018年行CTE的无急性阻塞性症状的CD患者,对CD进行常规随访。患者分为三组:非狭窄组、狭窄扩张2.5- 3cm组和狭窄扩张bbb3cm组。使用常规阈值和修正阈值计算狭窄患病率。随访期间的临床结果采用Cox比例风险回归和泊松回归进行分析,并对相关协变量进行调整。结果1022例患者(年龄中位数为35岁[IQR, 28-42岁],男性719例[70.4%])中,190例(18.6%)狭窄伴动脉扩张bbbb3 cm, 137例(13.4%)狭窄伴动脉扩张2.5-3 cm,采用新阈值,患病率为32.0%(1022例患者中有327例)。与非狭窄组相比,狭窄组(2.5- 3cm)和狭窄组(bbb3cm)急诊科就诊的风险均较高(校正风险比分别为2.13 [P < 0.001]和2.04 [P < 0.001];发生率比分别为2.46 [P < 0.001]和2.05 [P = 0.002])、小肠手术(调整后的HRs分别为2.27 [P = 0.006]和3.58 [P < 0.001])、症状性梗阻(调整后的HRs分别为7.99 [P < 0.001]和6.25 [P < 0.001])、小肠穿透(即脓肿或炎性肿块的窦或瘘的重新发生或进展)(调整后的HRs分别为3.47 [P < 0.001]和4.41 [P < 0.001])。结论:在CTE应用≥2.5 cm的狭窄扩张阈值可以识别更多没有急性阻塞性症状的CD患者的小肠狭窄,这些患者的不良临床结果风险增加。©RSNA, 2026本文提供补充材料。
{"title":"Revised Criterion for Identifying Small-Bowel Stricture in Crohn Disease at CT Enterography.","authors":"Se Jin Choi, Eun Sun Choi, Hae Young Kim, Seonok Kim, Jong Keon Jang, Yong Sik Yoon, Byong Duk Ye, Seong Ho Park","doi":"10.1148/radiol.253113","DOIUrl":"https://doi.org/10.1148/radiol.253113","url":null,"abstract":"<p><p>Background Recent guidelines lowered the prestenotic dilatation threshold from >3 cm to ≥2.5 cm for diagnosing small-bowel stricture at CT enterography (CTE) in Crohn disease (CD). Its impact on stricture prevalence and risk stratification is unknown. Purpose To quantify the increase in stricture prevalence when applying a threshold of ≥2.5 cm and to assess whether risks for adverse outcomes are stratified according to the new threshold. Materials and Methods This retrospective study included patients with CD without acute obstructive symptoms who underwent CTE from 2017 to 2018 for routine follow-up of CD. Patients were classified into three groups: nonstricture, stricture with a prestenotic dilatation of 2.5-3 cm, and stricture with a dilatation of >3 cm. Stricture prevalence was calculated using both conventional and revised thresholds. Clinical outcomes during follow-up were analyzed using a Cox proportional hazards regression and Poisson regression, adjusting for relevant covariates. Results Among 1022 patients (median age, 35 years [IQR, 28-42 years]; 719 [70.4%] men), 190 (18.6%) had strictures with a prestenotic dilatation of >3 cm, and 137 (13.4%) had strictures with a prestenotic dilatation of 2.5-3 cm-a prevalence of 32.0% (327 of 1022 patients) using the new threshold. Compared with the nonstricture group, both stricture groups-2.5-3 cm and >3 cm-had a higher risk for emergency department visits (adjusted hazard ratios [HRs], 2.13 [<i>P</i> < .001] and 2.04 [<i>P</i> < .001], respectively; incidence rate ratio, 2.46 [<i>P</i> < .001] and 2.05 [<i>P</i> = .002]), small-bowel surgery (adjusted HRs, 2.27 [<i>P</i> = .006] and 3.58 [<i>P</i> < .001]), symptomatic obstruction (adjusted HRs, 7.99 [<i>P</i> < .001] and 6.25 [<i>P</i> < .001]), and small-bowel penetration (ie, de novo occurrence or progression of a sinus or fistula to an abscess or inflammatory mass) (adjusted HRs, 3.47 [<i>P</i> < .001] and 4.41 [<i>P</i> < .001]). Conclusion Applying a prestenotic dilatation threshold of ≥2.5 cm at CTE enabled identification of small-bowel strictures in additional patients with CD without acute obstructive symptoms, and these patients had increased risks of adverse clinical outcomes. © RSNA, 2026 <i>Supplemental material is available for this article.</i></p>","PeriodicalId":20896,"journal":{"name":"Radiology","volume":"318 3","pages":"e253113"},"PeriodicalIF":15.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transarterial Radioembolization: Medical Staff Dosimetry for 90Y-Resin, 90Y-Glass, and 166Ho-PLLA Microspheres. 经动脉放射栓塞:90y -树脂、90y -玻璃和166Ho-PLLA微球的医务人员剂量测定
IF 15.2 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.251822
Christian Kühnel, Tabea Nikola Schmidt, Martin Freesmeyer, Miriam Schricke, Leonie Schreiber, Falk Gühne, René Aschenbach, Daniel Nißler, Amer Malouhi, Florian Bürckenmeyer, Thomas Weisheit, Sebastian Gröber, Robert Drescher, Marcel Scheithauer, Philipp Seifert

Background Transarterial radioembolization (TARE) of liver tumors exposes medical staff to radiation. Comparative data between three microspheres, 90Y-resin, 90Y-glass, and 166Ho-poly-L-lactic acid (PLLA), is lacking. Purpose To evaluate radiation exposure among medical staff in a real-world setting and provide reliable data for involved occupations and microspheres. Materials and Methods This prospective consecutive single-tertiary care center study included individuals undergoing TARE between February 2024 and February 2025. Radiation exposure of five radiopharmacists, seven interventional radiologists, five medical physics experts, five nuclear medicine physicians, eight radiologic technologists, and six nurses was monitored using multimodal dosimetric surveillance. Skin surface doses on hands, body doses on the chest, maximum procedural dose rates, and exposure times were measured per step. Comparisons between microspheres were conducted using analysis of variance and post hoc Tukey honestly significant difference tests. Pearson correlation coefficients for body doses, exposure times, and therapeutic radioactivity were determined. Results A total of 53 participants (mean age, 64 years ± 11; 42 male) underwent 60 TARE procedures (20 per microsphere type). Radiation exposure was generally low, with body and hand doses under 5 and under 350 µSv, respectively, per procedure. 166Ho-PLLA generated the highest body doses (maximum, 17 µSv) due to direct gamma radiation and higher therapeutic radioactivity. 90Y-resin generated the highest hand doses due to procedural handling (maximum, 309 µSv). Interventional radiologists received the highest body (mean, 2.5-4.5 µSv) and hand (mean, 146-309 µSv) doses per procedure among all occupations because of additional angiography. Maximum dose rate (adjusted to 1 GBq therapeutic radioactivity) was 1157 µSv/h during portioning of 90Y-resin by radiopharmacists. Results show moderate overall correlation between exposure time and body dose (rp = 0.51, P < .001). Conclusion TARE radiation exposure to medical staff was generally low, but highest for interventional radiologists. Since 90Y-resin microspheres result in high hand doses due to procedural handling, their portioning, assembly, and application should be performed with optimal efficiency by trained staff using long tweezers. © The Authors 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.

背景肝肿瘤经动脉放射栓塞术(TARE)使医务人员暴露在辐射下。90y -树脂、90y -玻璃和166ho -聚l -乳酸(PLLA)三种微球的比较数据缺乏。目的评估现实环境中医务人员的辐射暴露情况,为相关职业和微球提供可靠的数据。材料和方法本前瞻性连续单三级护理中心研究纳入了2024年2月至2025年2月期间接受TARE治疗的个体。采用多模态剂量监测方法监测5名放射药理学家、7名介入放射科医生、5名医学物理专家、5名核医学医师、8名放射技术专家和6名护士的辐射暴露情况。每一步测量手部皮肤表面剂量、胸部身体剂量、最大程序剂量率和暴露时间。微球间的比较采用方差分析和事后Tukey显著性差异检验。测定了人体剂量、照射时间和治疗放射性的Pearson相关系数。结果共53名参与者(平均年龄64岁±11岁;42名男性)接受了60次TARE手术(每个微球型20次)。辐射暴露一般较低,每次手术的身体和手部剂量分别低于5µSv和350µSv。由于直接伽马辐射和更高的治疗放射性,166Ho-PLLA产生最高的体剂量(最大17µSv)。由于程序性处理,90y树脂产生的手剂量最高(最大值为309µSv)。由于额外的血管造影,在所有职业中,介入放射科医生每次手术接受的身体(平均2.5-4.5µSv)和手部(平均146-309µSv)剂量最高。放射药理学家对90y -树脂的最大剂量率(调整为1 GBq治疗放射性)为1157µSv/h。结果显示,暴露时间与体剂量之间存在中度相关性(rp = 0.51, P < 0.001)。结论医务人员的TARE辐射暴露量普遍较低,但以介入放射科医生暴露量最高。由于90y -树脂微球由于程序性处理而导致高手剂量,因此应由训练有素的工作人员使用长镊子以最佳效率进行其分割,组装和应用。©作者2026。由北美放射学会在CC by 4.0许可下发布。
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引用次数: 0
Imaging in Advanced Epithelial Ovarian Cancer: Assessment of Peritoneal Spread. 晚期上皮性卵巢癌的影像学:腹膜扩散的评估。
IF 15.2 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.250116
Stephanie Nougaret, Yulia Lakhman, Krista E Suarez-Weiss, Krupa Patel-Lippman, Elizabeth Sadowski, Atul B Shinagare

Ovarian cancer affects over 250 000 women worldwide, with epithelial ovarian cancer accounting for approximately 90% of cases. Lack of effective screening and absence of early symptoms result in nearly 70% of patients presenting with late-stage disease. A distinct feature of advanced ovarian cancer is that peritoneal spread does not preclude curative surgical resection. Ovarian cancer is staged using the International Federation of Gynecology and Obstetrics, or FIGO, system, last updated in 2014. US is the first-line imaging modality for evaluating the symptomatic female pelvis, while MRI is the best modality for characterizing US-indeterminate adnexal masses. CT is the current standard of care to assess disease extent in advanced ovarian cancer, guiding treatment selection and surgical planning. Diffusion-weighted MRI may complement CT in the detection of disease in hard-to-resect areas. This article provides a practical approach to assessing and reporting peritoneal carcinomatosis, highlighting the importance of imaging in mapping disease extent and the added value of diffusion-weighted MRI in improving tumor visualization, especially in unresectable or hard-to-resect areas. The article also discusses the role of PET in initial staging and detecting recurrence. Furthermore, it highlights the role of radiologists as key members of the multidisciplinary team and emphasizes the importance of disease-specific structured reporting for clear communication.

卵巢癌影响全球超过25万名妇女,上皮性卵巢癌约占病例的90%。缺乏有效的筛查和缺乏早期症状导致近70%的患者出现晚期疾病。晚期卵巢癌的一个显著特征是腹膜扩散并不妨碍根治性手术切除。卵巢癌分期使用国际妇产科学联合会(FIGO)系统,该系统上次更新是在2014年。超声是评估有症状女性骨盆的一线成像方式,而MRI是表征超声不确定的附件肿块的最佳方式。CT是目前评估晚期卵巢癌疾病程度的护理标准,指导治疗选择和手术计划。弥散加权MRI可作为CT的补充,在难以切除的区域检测疾病。本文提供了一种评估和报告腹膜癌的实用方法,强调了成像在绘制疾病范围方面的重要性,以及弥散加权MRI在改善肿瘤可视化方面的附加价值,特别是在不可切除或难以切除的区域。本文还讨论了PET在早期分期和发现复发中的作用。此外,它强调了放射科医生作为多学科团队关键成员的作用,并强调了针对特定疾病的结构化报告对于清晰沟通的重要性。
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引用次数: 0
Ablation and Surgery Show Comparable Long-term Outcomes for T1a Renal Cell Carcinoma: A Danish Nationwide Registry Study. 消融和手术治疗T1a型肾细胞癌的长期疗效相当:丹麦全国登记研究
IF 19.7 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2026-03-01 DOI: 10.1148/radiol.251485
Johanne Ahrenfeldt,Jesper Jespersen,Pernille Tonnesen,Tommy Kjærgaard Nielsen,Anna Krarup Keller,Laura Iisager,Iben Lyskjær
Background Incidental diagnosis of small renal masses is placing increasing pressure on health care systems. While surgical resection remains standard, ablation has emerged as a less invasive alternative, potentially reducing complications, hospital stays, and costs. However, knowledge about outcomes following ablation remains limited. Purpose To compare the long-term outcomes of ablation, surgical resection, and nephrectomy in patients with T1a renal cell carcinoma (RCC). Materials and Methods This retrospective nationwide-registry cohort study included Danish adults diagnosed with T1a RCC between January 2013 and December 2021. Patients were treated with tumor ablation, surgical resection, or nephrectomy. The primary outcome was progression, defined as distant metastasis or local recurrence. Secondary outcomes included hospital length of stay and 30-day posttreatment hospital contacts, excluding routine scheduled follow-up visits. Progression was analyzed using competing risk regression, and hazard ratios with P values are reported. The χ2 test and Wilcoxon rank sum test were used for other group comparisons. Results A total of 1862 patients (median age, 64 years [IQR, 55-71 years]; 1305 male patients) were included. There was no evidence of a difference in progression risk between the ablation and resection groups after adjusting for confounders (hazard ratio, 1.46 [95% CI: 0.60, 3.56]; P = .40). Local recurrence was most frequent following ablation (ablation: 13 of 540 patients [2.41%]; resection: 12 of 1002 [1.20%]; nephrectomy: zero of 320 [0%]; P = .007), but was treatable with additional procedures. Distant metastasis was most frequent following nephrectomy (ablation: nine of 540 patients [1.67%]; resection: 19 of 1002 [1.90%]; nephrectomy: 14 of 320 [4.38%]; P = .02). Hospital stays were shortest for ablation (median hospitalization time: 0 days for ablation, 2 days for resection, 2 days for nephrectomy; P < .001). Ablation resulted in the fewest 30-day posttreatment hospital contacts (median number of contacts: one [IQR, 0-2] for ablation, one [IQR, 1-2] for resection, one [IQR, 1-2] for nephrectomy; P = .001), suggesting fewer complications with ablation. Conclusion In patients with T1a RCC, treatment with ablation demonstrated comparable progression risk but with fewer complications and shorter hospital stays. © The Author(s) 2026. Published by the Radiological Society of North America under a CC BY 4.0 license. Supplemental material is available for this article.
背景:小肾肿块的偶然诊断给卫生保健系统带来越来越大的压力。虽然手术切除仍是标准,但消融术已成为侵入性较小的替代方法,可能减少并发症、住院时间和费用。然而,对消融后结果的了解仍然有限。目的比较T1a型肾细胞癌(RCC)消融、手术切除和肾切除术的远期疗效。材料和方法这项回顾性全国登记队列研究纳入了2013年1月至2021年12月诊断为T1a RCC的丹麦成年人。患者接受肿瘤消融、手术切除或肾切除术。主要结局是进展,定义为远处转移或局部复发。次要结局包括住院时间和治疗后30天的医院接触,不包括常规随访。使用竞争风险回归分析进展,并报告具有P值的风险比。其他组间比较采用χ2检验和Wilcoxon秩和检验。结果共纳入患者1862例(中位年龄64岁[IQR, 55 ~ 71岁],男性1305例)。在调整混杂因素后,没有证据表明消融组和切除组之间的进展风险有差异(风险比为1.46 [95% CI: 0.60, 3.56]; P = 0.40)。局部复发在消融术后最为常见(消融术:540例患者中有13例[2.41%];切除术:1002例中有12例[1.20%];肾切除术:320例中没有一例[0%];P = .007),但可以通过其他手术治疗。肾切除术后最常发生远处转移(消融:540例中9例[1.67%];切除术:1002例中19例[1.90%];肾切除术:320例中14例[4.38%];P = 0.02)。消融术住院时间最短(中位住院时间:消融术0天,切除术2天,肾切除术2天;P < 0.001)。消融导致治疗后30天住院接触人数最少(接触人数中位数:消融1例[IQR, 0-2],切除术1例[IQR, 1-2],肾切除术1例[IQR, 1-2], P = .001),表明消融并发症较少。结论:在T1a型RCC患者中,消融治疗显示出相当的进展风险,但并发症较少,住院时间较短。©作者2026。由北美放射学会在CC by 4.0许可下发布。本文有补充材料。
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