利用柚木提取物绿色合成掺金氧化锡纳米粒子,在光动力疗法中的潜在应用

IF 1.8 Q2 SURGERY Photobiomodulation, photomedicine, and laser surgery Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI:10.1089/photob.2024.0052
Merat Karimi, Ehsan Sadeghi, Mostafa Zahedifar, Hamed Mirzaei, Majid Nejati, Michael R Hamblin
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引用次数: 0

摘要

目的:研究了利用柚子药用植物提取物绿色合成氧化锡(IV)(SnO2)、金(Au)纳米粒子(NPs)的方法:金(Au)纳米粒子(NPs)的绿色合成进行了研究,并对其作为光敏剂产生活性氧(ROS)进行了表征和测试。研究方法采用 3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑(MTT)技术研究了 NPs 对 C26 细胞的细胞毒性作用。结果表明,它们的毒性呈剂量依赖性。利用枸杞药用植物的提取物作为还原剂和稳定剂,首次实现了 SnO2:Au NPs 的绿色合成。研究了所制备的 NPs 在癌症光动力疗法(PDT)中的应用。结果显示用亚甲蓝和蒽证实了光敏剂在 UVA 辐射激发下能产生 ROS。使用 C26 细胞系和 MTT 试验对 SnO2:Au 的抗癌活性进行了体外研究,结果表明,使用 SnO2:Au NPs 进行光动力疗法可抑制癌细胞增殖。结论SnO2:Au NPs 的明显余辉可导致 ROS 的产生在光源关闭后持续数分钟。
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Green Synthesis of Au-Doped Tin Oxide Nanoparticles Using Teucrium Polium Extract with Potential Applications in Photodynamic Therapy.

Objective: The green synthesis of Tin(IV) oxide (SnO2): Gold (Au) nanoparticles (NPs) using Teucrium polium medicinal plant extract was investigated, and the NPs were characterized and tested as photosensitizers to produce reactive oxygen species (ROS). Methods: The cytotoxic effect on C26 cells was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) technique. The results showed their toxicity in a dose-dependent manner. The green synthesis of SnO2:Au NPs was achieved for the first time using an extract of T. polium medicinal plant as a reducing and stabilizing agent. The produced NPs were examined for their application in photodynamic therapy (PDT) for cancer. Results: Methylene blue and anthracene were used to confirm that the photosensitizer could produce ROS when excited with UVA radiation. The anticancer activity of SnO2:Au was investigated in vitro using the C26 cell line and an MTT assay, showing that PDT with SnO2:Au NPs could inhibit cancer cell proliferation. Conclusions: The significant afterglow of the SnO2:Au NPs could cause the generation of ROS to continue several minutes after switching off the light source.

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来源期刊
CiteScore
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期刊介绍: Photobiomodulation, Photomedicine, and Laser Surgery Editor-in-Chief: Michael R Hamblin, PhD Co-Editor-in-Chief: Heidi Abrahamse, PhD
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