利用智能手机技术对AuNP@自组装的4H-Chromene-增强型更昔洛韦进行比色检测:便携式医疗解决方案

IF 4.9 2区 化学 Q1 CHEMISTRY, ANALYTICAL Microchemical Journal Pub Date : 2024-09-20 DOI:10.1016/j.microc.2024.111734
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引用次数: 0

摘要

在我们的环境中,任何促进致癌的物质、辐射或放射性核素都是致癌物质。在目前的工作中,我们通过在 4H-chromene 衍生物的表面覆盖一层金纳米粒子壳对其进行了改性。有趣的是,更昔洛韦(Ganciclovir,GCV)在 4H-Chromene的Nap基团和金纳米粒子之间形成了桥梁,从而在AuNP@Self-assembled 4H-Chromene中显示出表面电荷还原特性。由于 Nap-GCV-AuNP 链接产生的电子转移机制,AuNPs 的表面电荷减少,从而导致团聚。因此,我们开发出了一种双模式的 GCV 比色传感器,既有溶液形式,又有便携式传感器条。该探针在理想情况下的线性范围为 0-74 nM,溶液检测限为 4 nM,纸条检测限为 3 nM。使用便携式可视读数器对人体血清中的实际应用进行评估后,结果令人满意,回收率为 102.1%,标准偏差为 ± 4%。令人惊讶的是,这是我们所知的第一项关于更昔洛韦比色检测的工作。
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AuNP@Self-assembled 4H-Chromene-Enhanced colorimetric detection of ganciclovir using smartphone Technology: Portable solutions for healthcare
Any substance, radiation, or radionuclide in our environment that promotes carcinogenesis is a cancerogen. In the current work, we modified the 4H-chromene derivative by covering its surface with a shell of gold nanoparticles. Interestingly, ganciclovir (GCV) formed a bridge between the Nap-group of 4H-chromene and gold nanoparticles to display surface charge reduction properties in AuNP@Self-assembled 4H-Chromene. The surface charge of AuNPs is reduced as a result of the electron transfer mechanism brought on by the creation of the Nap-GCV-AuNP link, which leads to agglomeration. This led to the development of a dual-mode colorimetric sensor for GCV that incorporates solution form and portable sensor strip. The probe showed a linear range of 0–74 nM under ideal circumstances, with a detection limit of 4 nM in solution and 3 nM on paper strip detection. An evaluation of the practical utility in human serum using a portable visual read-out produced satisfactory findings, with a recovery percentage of 102.1 % and a standard deviation of ± 4 %. Surprisingly, this is the first work on the colorimetric detection of Ganciclovir that we are aware of.
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来源期刊
Microchemical Journal
Microchemical Journal 化学-分析化学
CiteScore
8.70
自引率
8.30%
发文量
1131
审稿时长
1.9 months
期刊介绍: The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.
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