超重和不同程度的肥胖与主观幸福感和抑郁症状之间的关系:两项孟德尔随机抽样研究

IF 3.5 2区 医学 Q2 PSYCHIATRY Journal of Psychosomatic Research Pub Date : 2024-09-19 DOI:10.1016/j.jpsychores.2024.111940
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引用次数: 0

摘要

方法将超重(体重指数≥ 25 kg/m2)、1 级肥胖(体重指数≥ 30 kg/m2)和 2 级肥胖(体重指数≥ 35 kg/m2)的全基因组关联研究(GWAS)数据作为暴露因子。抑郁症状和腰围的 GWAS 数据摘要被用作结果。结果MR分析表明,遗传预测的超重(IVW β = 0.033; 95 %CI 0.008-0.057; P = 0.010)和1级肥胖(IVW β = -0.033; 95 %CI -0.047-0.020; P < 0.001)与抑郁症状的增加有因果关系。遗传预测的 2 级肥胖(IVW β = 1.428; 95 %CI 1.193-1.710; P <0.001)与腰围减少有关。没有强有力的证据表明遗传预测的超重和一级肥胖与腰围之间存在因果关系。同样,遗传预测的 2 级和 3 级肥胖也没有显示出与抑郁症状有因果关系的有力证据。敏感性分析表明,两者之间存在类似程度的关系。结论这项基于基因的 MR 研究表明,超重和 1 级肥胖可能会增加抑郁症状,但不会降低腰围。与此相反,2 级肥胖可能会降低 SWB,但不会增加抑郁症状。
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The association between overweight and varying degrees of obesity with subjective well-being and depressive symptoms: A two sample Mendelian randomization study

Objective

This study utilized the Mendelian randomization (MR) method to elucidate the causal relationship between genetically predicted overweight and various degrees of obesity with depressive symptoms and subjective well-being (SWB).

Methods

Pooled genome-wide association studies (GWAS) data for overweight (BMI ≥ 25 kg/m2), class 1 obesity (BMI ≥ 30 kg/m2), and class 2 obesity (BMI ≥ 35 kg/m2) were used as exposures. Summary GWAS data for depressive symptoms and SWB were used as outcomes. Multiple MR methods, primarily inverse-variance weighted (IVW), were applied, and sensitivity analyses were conducted to assess heterogeneity and pleiotropy.

Results

The MR analysis provided evidence that genetically predicted overweight(IVW β = 0.033; 95 %CI 0.008–0.057; P = 0.010) and class 1 obesity(IVW β = −0.033; 95 %CI -0.047 – -0.020; P < 0.001) were causally associated with increased depressive symptoms. Genetically predicted class 2 obesity(IVW β = 1.428; 95 %CI 1.193–1.710; P < 0.001) were associated with reduced SWB. There was no strong evidence of a causal association between genetically predicted overweight and class 1 obesity with SWB. Similarly, genetically predicted class 2 and class 3 obesity did not show strong evidence of a causal association with depressive symptoms. Sensitivity analysis revealed relationships of a similar magnitude.

Conclusion

This genetically informed MR study suggests that Overweight and class 1 obesity may causally increased depressive symptoms but not decrease SWB. In contrast, class 2 obesity may causally decrease SWB but not increase depressive symptoms.
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来源期刊
Journal of Psychosomatic Research
Journal of Psychosomatic Research 医学-精神病学
CiteScore
7.40
自引率
6.40%
发文量
314
审稿时长
6.2 weeks
期刊介绍: The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.
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