CABINET 提出卡博替尼是治疗 NET 的新方案

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-09-24 DOI:10.1038/s41571-024-00949-0
David Killock
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引用次数: 0

摘要

晚期神经内分泌肿瘤(NET)患者在接受1-2线系统治疗后病情恶化,治疗选择非常有限。在 CABINET 试验中,既往接受过至少一种 FDA 批准的系统疗法治疗的局部晚期或转移性良好或中度分化胰腺外(n = 203)或胰腺(n = 95)NET 患者被 2:1 随机分配至卡博替尼或安慰剂治疗。大多数患者曾接受过177Lu-dotatate(约占59%)和/或依维莫司(约占72%)治疗,约26%的胰腺NET患者曾接受过舒尼替尼治疗。无进展生存期(PFS)是主要终点。
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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