{"title":"用功能客体装饰的卵黄壳Pst@SiO2:高效分离无载体添加 177Lu 的新型固相萃取剂","authors":"","doi":"10.1016/j.seppur.2024.129802","DOIUrl":null,"url":null,"abstract":"<div><div>With the rapid development of <sup>177</sup>Lu-related radiopharmaceuticals, there is an urgent need for large-scale production of <sup>177</sup>Lu efficiently. In this work, we employed yolk-shell Pst@SiO<sub>2</sub> to accommodate 2-ethylhexyl 2-ethylhexylphosphonic acid (HEH[EHP]), obtaining a material with ideal microstructure and adequate functionality to isolate Lu from Yb effectively. <sup>177</sup>Lu isolation on HEH[EHP]-Pst@SiO<sub>2</sub> dynamic column has been demonstrated to be influenced by various parameters such as the initial target solution, the eluent property, and the separation temperature. Most importantly, an effective separation process including primary separation and secondary purification has been established based on plenty of simulated experiments and radioactively tracing investigations. As a result, NCA <sup>177</sup>Lu with high radionuclide and radiochemical purity (≥99.99 %) and excellent decontamination factor (10<sup>4</sup>) from Yb can be acquired in good recovery (>60%). This work provides not only a candidate for NCA <sup>177</sup>Lu production but also some important hints for the separation of other heavy lanthanides.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Yolk-Shell Pst@SiO2 decorated with functional guests: A new solid-phase extractant for highly effective separation of no carrier added 177Lu\",\"authors\":\"\",\"doi\":\"10.1016/j.seppur.2024.129802\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>With the rapid development of <sup>177</sup>Lu-related radiopharmaceuticals, there is an urgent need for large-scale production of <sup>177</sup>Lu efficiently. In this work, we employed yolk-shell Pst@SiO<sub>2</sub> to accommodate 2-ethylhexyl 2-ethylhexylphosphonic acid (HEH[EHP]), obtaining a material with ideal microstructure and adequate functionality to isolate Lu from Yb effectively. <sup>177</sup>Lu isolation on HEH[EHP]-Pst@SiO<sub>2</sub> dynamic column has been demonstrated to be influenced by various parameters such as the initial target solution, the eluent property, and the separation temperature. Most importantly, an effective separation process including primary separation and secondary purification has been established based on plenty of simulated experiments and radioactively tracing investigations. As a result, NCA <sup>177</sup>Lu with high radionuclide and radiochemical purity (≥99.99 %) and excellent decontamination factor (10<sup>4</sup>) from Yb can be acquired in good recovery (>60%). This work provides not only a candidate for NCA <sup>177</sup>Lu production but also some important hints for the separation of other heavy lanthanides.</div></div>\",\"PeriodicalId\":427,\"journal\":{\"name\":\"Separation and Purification Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.1000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Separation and Purification Technology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S138358662403541X\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Separation and Purification Technology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S138358662403541X","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
Yolk-Shell Pst@SiO2 decorated with functional guests: A new solid-phase extractant for highly effective separation of no carrier added 177Lu
With the rapid development of 177Lu-related radiopharmaceuticals, there is an urgent need for large-scale production of 177Lu efficiently. In this work, we employed yolk-shell Pst@SiO2 to accommodate 2-ethylhexyl 2-ethylhexylphosphonic acid (HEH[EHP]), obtaining a material with ideal microstructure and adequate functionality to isolate Lu from Yb effectively. 177Lu isolation on HEH[EHP]-Pst@SiO2 dynamic column has been demonstrated to be influenced by various parameters such as the initial target solution, the eluent property, and the separation temperature. Most importantly, an effective separation process including primary separation and secondary purification has been established based on plenty of simulated experiments and radioactively tracing investigations. As a result, NCA 177Lu with high radionuclide and radiochemical purity (≥99.99 %) and excellent decontamination factor (104) from Yb can be acquired in good recovery (>60%). This work provides not only a candidate for NCA 177Lu production but also some important hints for the separation of other heavy lanthanides.
期刊介绍:
Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.