Wnt/β-catenin 信号通路在异位骨化和骨化相关疾病中的参与

Yike Zhao, Fangzhou Liu, Yiran Pei, Fengyu Lian, Hui Lin
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引用次数: 0

摘要

异位骨化(HO)是一种病理状态,其特点是在软组织内形成骨骼。异位骨化是骨形成程序异常激活的结果,其中涉及多种信号通路,包括Wnt/β-catenin、BMP和刺猬信号。Wnt/β-catenin 信号通路是对各种基本活动至关重要的保守通路,已被发现在病理骨形成过程中发挥重要作用。它在 HO 发育过程中调节血管生成、软骨细胞肥大和成骨细胞分化。更重要的是,Wnt 信号与其他因子(包括 BMP、刺猬信号、YAP)之间的相互影响可能对 HO 有利。此外,一些miRNA也可能通过调控Wnt信号参与HO的形成。本综述旨在总结Wnt/β-catenin信号在HO发病机制中的作用、其与相关分子的相互作用以及针对Wnt/β-catenin信号的潜在预防和治疗措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Involvement of the Wnt/β-catenin signalling pathway in heterotopic ossification and ossification-related diseases

Heterotopic ossification (HO) is a pathological condition characterized by the formation of bone within soft tissues. The development of HO is a result of abnormal activation of the bone formation programs, where multiple signalling pathways, including Wnt/β-catenin, BMP and hedgehog signalling, are involved. The Wnt/β-catenin signalling pathway, a conserved pathway essential for various fundamental activities, has been found to play a significant role in pathological bone formation processes. It regulates angiogenesis, chondrocyte hypertrophy and osteoblast differentiation during the development of HO. More importantly, the crosstalk between Wnt signalling and other factors including BMP, Hedgehog signalling, YAP may contribute in a HO-favourable manner. Moreover, several miRNAs may also be involved in HO formation via the regulation of Wnt signalling. This review aims to summarize the role of Wnt/β-catenin signalling in the pathogenesis of HO, its interactions with related molecules, and potential preventive and therapeutic measures targeting Wnt/β-catenin signalling.

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期刊介绍: The Journal of Cellular and Molecular Medicine serves as a bridge between physiology and cellular medicine, as well as molecular biology and molecular therapeutics. With a 20-year history, the journal adopts an interdisciplinary approach to showcase innovative discoveries. It publishes research aimed at advancing the collective understanding of the cellular and molecular mechanisms underlying diseases. The journal emphasizes translational studies that translate this knowledge into therapeutic strategies. Being fully open access, the journal is accessible to all readers.
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