{"title":"小鼠早期发育过程中无活性 X 染色体的结构重塑","authors":"Edda G. Schulz, Alexandra Martitz","doi":"10.1038/s41588-024-01936-y","DOIUrl":null,"url":null,"abstract":"The mammalian inactive X chromosome shows unusual folding dominated by large-scale structures. A study finds a megadomain structure with a boundary at the Xist locus, preceding the well-known Dxz4-separated megadomains in somatic cells.","PeriodicalId":18985,"journal":{"name":"Nature genetics","volume":"56 10","pages":"2004-2005"},"PeriodicalIF":31.7000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Structural remodeling of the inactive X chromosome during early mouse development\",\"authors\":\"Edda G. Schulz, Alexandra Martitz\",\"doi\":\"10.1038/s41588-024-01936-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The mammalian inactive X chromosome shows unusual folding dominated by large-scale structures. A study finds a megadomain structure with a boundary at the Xist locus, preceding the well-known Dxz4-separated megadomains in somatic cells.\",\"PeriodicalId\":18985,\"journal\":{\"name\":\"Nature genetics\",\"volume\":\"56 10\",\"pages\":\"2004-2005\"},\"PeriodicalIF\":31.7000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature genetics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.nature.com/articles/s41588-024-01936-y\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature genetics","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41588-024-01936-y","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
摘要
哺乳动物的非活性 X 染色体显示出以大规模结构为主的不寻常折叠。一项研究发现，在体细胞中众所周知的Dxz4分隔的巨型结构之前，Xist基因座上有一个具有边界的巨型结构。
Structural remodeling of the inactive X chromosome during early mouse development
The mammalian inactive X chromosome shows unusual folding dominated by large-scale structures. A study finds a megadomain structure with a boundary at the Xist locus, preceding the well-known Dxz4-separated megadomains in somatic cells.
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