Mu Zi Liang, Peng Chen, Ying Tang, Yu Yan Liang, Shu Han Li, Guang Yun Hu, Zhe Sun, Yuan Liang Yu, Alex Molassiotis, M. Tish Knobf, Zeng Jie Ye
{"title":"乳腺癌患者大脑结构连通性与 1 年去势之间的关系：纵向弥散张量成像研究","authors":"Mu Zi Liang, Peng Chen, Ying Tang, Yu Yan Liang, Shu Han Li, Guang Yun Hu, Zhe Sun, Yuan Liang Yu, Alex Molassiotis, M. Tish Knobf, Zeng Jie Ye","doi":"10.1155/2024/5595912","DOIUrl":null,"url":null,"abstract":"<div>\n <p><b>Purposes:</b> This study aims to explore the association between brain structural connectivity and 1-year demoralization in patients with newly diagnosed breast cancer.</p>\n <p><b>Methods:</b> Patients were enrolled from a multicenter longitudinal program named as <i>Be Resilient to Breast Cancer</i> (BRBC) between 2017 and 2019. Brain structural connectivity was assessed with diffusion tensor imaging (DTI) at baseline and the demoralization scale II collected self-report data at baseline and 1 year later. A data-driven correlational tractography was performed to recognize significant neural pathways associated with the group membership (increased vs. nonincreased demoralization). The incremental prediction values of Quantitative Anisotropy (QA) extracted from the significant white matter tracts against the group membership were evaluated.</p>\n <p><b>Results:</b> 21.2% (<i>N</i> = 31) reported increased 1-year demoralization. Inferior fronto-occipital fasciculus (IFOF) was associated with 1-year demoralization in breast cancer. The incremental prediction values of QAs in net reclassification improvement (NRI) and integrated discrimination improvement (IDI) ranged from 8.11% to 46.89% and 9.12% to 23.95%, respectively, over the conventional tumor-nodal metatasis (TNM) staging model.</p>\n <p><b>Conclusion:</b> Anisotropy in IFOF is a potential prediction neuromarker to 1-year demoralization in patients with newly diagnosed breast cancer.</p>\n <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03026374</p>\n </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5595912","citationCount":"0","resultStr":"{\"title\":\"Associations Between Brain Structural Connectivity and 1-Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study\",\"authors\":\"Mu Zi Liang, Peng Chen, Ying Tang, Yu Yan Liang, Shu Han Li, Guang Yun Hu, Zhe Sun, Yuan Liang Yu, Alex Molassiotis, M. Tish Knobf, Zeng Jie Ye\",\"doi\":\"10.1155/2024/5595912\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><b>Purposes:</b> This study aims to explore the association between brain structural connectivity and 1-year demoralization in patients with newly diagnosed breast cancer.</p>\\n <p><b>Methods:</b> Patients were enrolled from a multicenter longitudinal program named as <i>Be Resilient to Breast Cancer</i> (BRBC) between 2017 and 2019. Brain structural connectivity was assessed with diffusion tensor imaging (DTI) at baseline and the demoralization scale II collected self-report data at baseline and 1 year later. A data-driven correlational tractography was performed to recognize significant neural pathways associated with the group membership (increased vs. nonincreased demoralization). The incremental prediction values of Quantitative Anisotropy (QA) extracted from the significant white matter tracts against the group membership were evaluated.</p>\\n <p><b>Results:</b> 21.2% (<i>N</i> = 31) reported increased 1-year demoralization. Inferior fronto-occipital fasciculus (IFOF) was associated with 1-year demoralization in breast cancer. The incremental prediction values of QAs in net reclassification improvement (NRI) and integrated discrimination improvement (IDI) ranged from 8.11% to 46.89% and 9.12% to 23.95%, respectively, over the conventional tumor-nodal metatasis (TNM) staging model.</p>\\n <p><b>Conclusion:</b> Anisotropy in IFOF is a potential prediction neuromarker to 1-year demoralization in patients with newly diagnosed breast cancer.</p>\\n <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03026374</p>\\n </div>\",\"PeriodicalId\":55179,\"journal\":{\"name\":\"Depression and Anxiety\",\"volume\":\"2024 1\",\"pages\":\"\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5595912\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Depression and Anxiety\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/2024/5595912\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Depression and Anxiety","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/5595912","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Associations Between Brain Structural Connectivity and 1-Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study
Purposes: This study aims to explore the association between brain structural connectivity and 1-year demoralization in patients with newly diagnosed breast cancer.
Methods: Patients were enrolled from a multicenter longitudinal program named as Be Resilient to Breast Cancer (BRBC) between 2017 and 2019. Brain structural connectivity was assessed with diffusion tensor imaging (DTI) at baseline and the demoralization scale II collected self-report data at baseline and 1 year later. A data-driven correlational tractography was performed to recognize significant neural pathways associated with the group membership (increased vs. nonincreased demoralization). The incremental prediction values of Quantitative Anisotropy (QA) extracted from the significant white matter tracts against the group membership were evaluated.
Results: 21.2% (N = 31) reported increased 1-year demoralization. Inferior fronto-occipital fasciculus (IFOF) was associated with 1-year demoralization in breast cancer. The incremental prediction values of QAs in net reclassification improvement (NRI) and integrated discrimination improvement (IDI) ranged from 8.11% to 46.89% and 9.12% to 23.95%, respectively, over the conventional tumor-nodal metatasis (TNM) staging model.
Conclusion: Anisotropy in IFOF is a potential prediction neuromarker to 1-year demoralization in patients with newly diagnosed breast cancer.
期刊介绍：
Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.
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