Proteomic signatures of healthy dietary patterns are associated with lower risks of major chronic diseases and mortality

Healthy dietary patterns have been linked to a decreased risk of chronic diseases. However, it remains uncertain whether proteomic signatures can reflect proteome response to healthy diet patterns, and whether these proteomic signatures are associated with health outcomes. Using data from the UK Biobank including Olink plasma proteins, we identified substantial proteomic variation in relation to adherence to eight healthy dietary patterns. The proteomic signatures, reflecting adherence and proteome response to healthy dietary patterns, were prospectively associated with lower risks of diabetes, cardiovascular diseases, chronic respiratory diseases, chronic kidney diseases and cancers, along with longer life expectancy, even after adjusting for corresponding dietary patterns. These findings suggest proteomic signatures have the potential to complement traditional dietary assessments and deepen our understanding of the relationships between dietary patterns and chronic diseases. The use of biomarkers to complement traditional dietary assessment methods can help strengthen findings from nutritional epidemiologic studies. This study identifies plasma proteomic signatures that reflect the response to healthy dietary patterns and are associated with reduced incidence of chronic disease and mortality.