新四环系统的合成：羟基、硫酰基和氨基取代的二苯并[c,f][1,2]硫氮杂卓 S,S-二氧化物的桥式衍生物

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC European Journal of Organic Chemistry Pub Date : 2024-09-27 DOI:10.1002/ejoc.202400835

Gábor Berecz, Dávid Szabó, András Dancsó, Mária Tóthné Lauritz, Loránd Kiss, Gyula Simig, Balázs Volk

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引用次数: 0

摘要

为了继续致力于以抗抑郁药物替奈普汀的 6,11-二氢二苯并[c,f][1,2]硫氮杂卓 5,5-二氧化物为核心合成新的环系统，我们在磺酰胺分子的氮原子与三环 11 位的 N、O 或 S 取代基之间加入了二碳桥和/或三碳桥。本文介绍了 5 种新环系统的合成方法，并用几个目标化合物进行了演示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of New Tetracyclic Ring Systems: Bridged Derivatives of Hydroxy-, Sulfanyl- and Amino-Substituted Dibenzo[c,f][1,2]thiazepine S,S-Dioxides

In continuation of our commitment to the synthesis of new ring systems based on the 6,11-dihydrodibenzo[c,f][1,2]thiazepin 5,5-dioxide core of the antidepressant drug tianeptine, we have incorporated two- and/or three-carbon bridges between the nitrogen atom of the sulfonamide moiety and the N-, O- or S-substituent at position 11 of the tricycle. The synthesis of 5 new ring systems is described and demonstrated with several target compounds.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.