具有伤口愈合抗菌活性的 Fe3O4/BiOI/Ag 空心微电机

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Nano Materials Pub Date : 2024-09-12 DOI:10.1021/acsanm.4c0430410.1021/acsanm.4c04304
Hangyu Luo, Xiaofeng Liu, Zhenbang Meng, Han Wang, Qi He, Ri Chen and Wenxia Wang*, 
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引用次数: 0

摘要

抗菌微电机具有引人入胜的特性,是生物医学和环境领域的研究前沿。虽然单动力微电机在复杂的生物环境中实现高效推进仍面临一些挑战,但本文通过两个简单步骤合成了具有中空结构的 Fe3O4/BiOI/Ag (FBA)双动力微电机,无需任何复杂设备。在这一独特的设计中,展示了由磁刺激/可见光驱动的 FBA 微电机的高效推进。令人印象深刻的是,在不添加有毒燃料的情况下,微电机能够以 119.2 ± 5.9 μm s-1 的惊人速度灵活推进。利用其运动能力、细菌捕获能力和光催化能力,空心 FBA 微电机可完全灭活 1 × 107 CFU mL-1 的大肠杆菌(E. coli)。FBA 在金黄色葡萄球菌(S. aureus)和铜绿假单胞菌(P. aeruginosa)抗菌应用中的理想通用性得到了证实。此外,FBA 微电机对大肠杆菌、耐甲氧西林金黄色葡萄球菌(MRSA)和铜绿假单胞菌具有抗生物膜能力。值得一提的是,它们还具有理想的生物相容性和较低的毒性。更重要的是,FBA 微电机能有效加速金黄色葡萄球菌感染伤口的愈合,且不会造成不良影响。这项工作提供了一种创新的策略,可为各种环境和生物医学应用轻松设计双推进微电机。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Fe3O4/BiOI/Ag Hollow Micromotors with Antibacterial Activity for Wound Healing

Antibacterial micromotors with intriguing properties have represented frontiers of research in the biomedical and environmental fields. While single-powered micromotors still encounter some challenges for efficient propulsion in an intricate biological environment, herein, dual-propelled Fe3O4/BiOI/Ag (FBA) micromotors with hollow structure were synthesized via two facile steps without involving any sophisticated equipment. In this unique design, efficient propulsion of an FBA micromotor powered by magnetic stimuli/visible light was demonstrated. Impressively, the micromotor was capable of flexible propulsion with a remarkable velocity of 119.2 ± 5.9 μm s–1 without addition of toxic fuel. Taking advantage of the locomotion, bacterial capture ability, and photocatalytic capacity, 1 × 107 CFU mL–1 Escherichia coli (E. coli) can be totally inactivated by hollow FBA micromotors. The ideal universality of FBA for antibacterial application toward Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) was confirmed. Besides, the FBA micromotors manifested antibiofilm capacity toward E. coli, methicillin-resistant S. aureus (MRSA), and P. aeruginosa. It is worth mentioning that they also displayed ideal biocompatibility and lower toxicity. More importantly, the FBA micromotors can effectively accelerate S. aureus-infected wound healing without causing adverse effects. This work offers an innovative strategy for facile design of dual-propelled micromotors for various environmental and biomedical applications.

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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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