SoYoung Ahn , Parivash Jamrasi , Byunggul Lim , Ji-won Seo , Xinxing Li , Shu Jiang , Yunho Sung , Seo Hyun Ahn , Chaeyoung Shin , Dongjin Noh , Bora Jin , Seonjoo Lee , Ki Won Lee , Jin Soo Kim , Young Tae Koo , Wook Song
{"title":"草药提取物（林奈鹿、当归和黄芪）可改善慢性疲劳：随机、安慰剂对照、双盲试验","authors":"SoYoung Ahn , Parivash Jamrasi , Byunggul Lim , Ji-won Seo , Xinxing Li , Shu Jiang , Yunho Sung , Seo Hyun Ahn , Chaeyoung Shin , Dongjin Noh , Bora Jin , Seonjoo Lee , Ki Won Lee , Jin Soo Kim , Young Tae Koo , Wook Song","doi":"10.1016/j.imr.2024.101085","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Chronic fatigue syndrome (CFS) reduces the health-related quality of life in the working-age population; however, studies have rarely investigated this group. A mixture of Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge (CAA) may be an effective anti-fatigue supplement. However, few clinical trials have explored the anti-fatigue effects of herbal medicines in human participants. Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial.</div></div><div><h3>Methods</h3><div>In an 8-week trial, 80 patients with chronic fatigue symptoms were randomly assigned to the CAA (43.5 ± 1.2 years) or placebo group (41.8 ± 1.3 years). Fatigue and cardiorespiratory endurance were measured at baseline, interim, and post-intervention. Fatigue-related blood biomarkers were assessed before and at the end of the intervention.</div></div><div><h3>Results</h3><div>A significant improvement in overall fatigue scores was observed on the fatigue severity scale (<em>p</em> = 0.038), multidimensional fatigue inventory (<em>p</em> = 0.037), and 24-hour visual analog scale (<em>p</em> = 0.002) in the CAA group compared to those in the placebo group. Fatigue improvement was observed in the CAA group, as well as physiological variables, such as increased maximal exercise time to exhaustion (<em>p</em> = 0.003), distance until exhaustion (<em>p</em> = 0.003), and maximum oxygen consumption (<em>p</em> = 0.039).</div></div><div><h3>Conclusion</h3><div>CAA positively and significantly affected fatigue and cardiorespiratory endurance in patients with chronic fatigue, suggesting the potential use of herbal supplements for treating chronic fatigue.</div></div><div><h3>Trial registration</h3><div>Clinical Research Information Service (CRIS, <span><span>https://cris.nih.go.kr/</span><svg><path></path></svg></span>): KCT0005613.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial\",\"authors\":\"SoYoung Ahn , Parivash Jamrasi , Byunggul Lim , Ji-won Seo , Xinxing Li , Shu Jiang , Yunho Sung , Seo Hyun Ahn , Chaeyoung Shin , Dongjin Noh , Bora Jin , Seonjoo Lee , Ki Won Lee , Jin Soo Kim , Young Tae Koo , Wook Song\",\"doi\":\"10.1016/j.imr.2024.101085\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Chronic fatigue syndrome (CFS) reduces the health-related quality of life in the working-age population; however, studies have rarely investigated this group. A mixture of Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge (CAA) may be an effective anti-fatigue supplement. However, few clinical trials have explored the anti-fatigue effects of herbal medicines in human participants. Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial.</div></div><div><h3>Methods</h3><div>In an 8-week trial, 80 patients with chronic fatigue symptoms were randomly assigned to the CAA (43.5 ± 1.2 years) or placebo group (41.8 ± 1.3 years). Fatigue and cardiorespiratory endurance were measured at baseline, interim, and post-intervention. Fatigue-related blood biomarkers were assessed before and at the end of the intervention.</div></div><div><h3>Results</h3><div>A significant improvement in overall fatigue scores was observed on the fatigue severity scale (<em>p</em> = 0.038), multidimensional fatigue inventory (<em>p</em> = 0.037), and 24-hour visual analog scale (<em>p</em> = 0.002) in the CAA group compared to those in the placebo group. Fatigue improvement was observed in the CAA group, as well as physiological variables, such as increased maximal exercise time to exhaustion (<em>p</em> = 0.003), distance until exhaustion (<em>p</em> = 0.003), and maximum oxygen consumption (<em>p</em> = 0.039).</div></div><div><h3>Conclusion</h3><div>CAA positively and significantly affected fatigue and cardiorespiratory endurance in patients with chronic fatigue, suggesting the potential use of herbal supplements for treating chronic fatigue.</div></div><div><h3>Trial registration</h3><div>Clinical Research Information Service (CRIS, <span><span>https://cris.nih.go.kr/</span><svg><path></path></svg></span>): KCT0005613.</div></div>\",\"PeriodicalId\":13644,\"journal\":{\"name\":\"Integrative Medicine Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Integrative Medicine Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213422024000659\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integrative Medicine Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213422024000659","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Herbal extract (Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial
Background
Chronic fatigue syndrome (CFS) reduces the health-related quality of life in the working-age population; however, studies have rarely investigated this group. A mixture of Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge (CAA) may be an effective anti-fatigue supplement. However, few clinical trials have explored the anti-fatigue effects of herbal medicines in human participants. Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial.
Methods
In an 8-week trial, 80 patients with chronic fatigue symptoms were randomly assigned to the CAA (43.5 ± 1.2 years) or placebo group (41.8 ± 1.3 years). Fatigue and cardiorespiratory endurance were measured at baseline, interim, and post-intervention. Fatigue-related blood biomarkers were assessed before and at the end of the intervention.
Results
A significant improvement in overall fatigue scores was observed on the fatigue severity scale (p = 0.038), multidimensional fatigue inventory (p = 0.037), and 24-hour visual analog scale (p = 0.002) in the CAA group compared to those in the placebo group. Fatigue improvement was observed in the CAA group, as well as physiological variables, such as increased maximal exercise time to exhaustion (p = 0.003), distance until exhaustion (p = 0.003), and maximum oxygen consumption (p = 0.039).
Conclusion
CAA positively and significantly affected fatigue and cardiorespiratory endurance in patients with chronic fatigue, suggesting the potential use of herbal supplements for treating chronic fatigue.
Trial registration
Clinical Research Information Service (CRIS, https://cris.nih.go.kr/): KCT0005613.
期刊介绍：
Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.
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