Sujan Banik , Antara Ghosh , Tomoyuki Takano , Masao Tsukamoto , Soo Takasu , Masaki Honda
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引用次数: 0
摘要
虽然类胡萝卜素在膳食来源中最常见的是全E-异构体,但有些类胡萝卜素在皮肤中积聚为Z-异构体;它们的作用在很大程度上还不为人所知。本研究调查了叶黄素和岩藻黄素这两种类黄素的 E/Z 异构体对其抗氧化潜力和皮肤相关生物活性的影响。对紫外线(UV)阻隔能力的评估表明,富含 Z-异构体的叶黄素和福柯黄素在抵御 UV-A 和 UV-B 辐射方面表现出色,其中富含 Z-异构体的叶黄素具有更高的 UV-B 防护能力。抗氧化试验表明,富含全E和Z-异构体的叶黄素和福柯黄素具有很强的清除单线态氧和羟自由基的活性。此外,富含 Z 异构体的叶黄素和福柯黄素与全 E 异构体相比,具有更强的脂质过氧化清除能力。在几种体外实验中,叶黄素和狐黄素的两种异构体都表现出有效的皮肤抗衰老和皮肤美白效果,包括抗弹性蛋白酶和抗酪氨酸酶活性。这些研究结果表明,几何异构体可提高类胡萝卜素在护肤应用中的疗效。
Geometrical isomers of lutein and fucoxanthin: Unveiling their antioxidant potentials and skin-related biological activities
Although carotenoids are most commonly found in dietary sources as all-E-isomers, some carotenoids accumulate in the skin as Z-isomers; their roles are largely unknown. This study investigated the effects of E/Z-isomers of lutein and fucoxanthin, two xanthophyll carotenoids, on their antioxidant potential and skin-related biological activities. Evaluation of ultraviolet (UV)-blocking abilities demonstrated the superior performance of Z-isomer-rich lutein and fucoxanthin against UV-A and UV-B radiation, with Z-isomer-rich lutein exhibiting higher UV-B protection. Antioxidant assays revealed that all-E- and Z-isomer-rich lutein and fucoxanthin had potent singlet oxygen and hydroxyl radical scavenging activities. Moreover, Z-isomer-rich lutein and fucoxanthin exhibited enhanced lipid peroxidation scavenging compared with their all-E counterparts. Both isomers of lutein and fucoxanthin exhibited potent skin-antiaging and skin-whitening effects in several in vitro assays, including anti-elastase and anti-tyrosinase activities. These findings suggest that geometric isomers may enhance the therapeutic efficacy of carotenoids in skin care applications.