核磷葡聚糖酶-1 在肝细胞癌中的表达和临床意义

IF 1.3 4区 医学 Q3 ANATOMY & MORPHOLOGY Applied Immunohistochemistry & Molecular Morphology Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI:10.1097/PAI.0000000000001225
Yechen Xia, Yan An, Riming Jin, Wentao Huang, Guang-Zhi Jin, Jing Xu
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引用次数: 0

摘要

本研究旨在评估磷酸葡萄糖转氨酶-1(PGM1)表达对肝细胞癌(HCC)患者预后的预测价值。通过组织芯片中的免疫组织化学方法评估了 PGM1 的表达。通过χ2检验和Cox回归分别分析了PGM1表达水平与病理参数和预后值的关系。用接收者操作特征曲线计算了独立危险因素预测预后的准确性。对HCC患者来源的异种移植模型进行了核PGM1抗肿瘤作用的评估。结果显示,PGM1 在 HCC 组织中表达量较低。核 PGM1 是总生存期和复发时间的独立预后因素。Cox回归显示,核PGM1、血清α-胎儿蛋白、肝硬化和TNM分期是HCC的独立风险预测因子。接收者操作特征曲线显示,与单独的TNM分期相比,将独立的预测因子结合在一起具有更好的预后价值。此外,患者来源的异种移植模型显示了核 PGM1 的抗肿瘤作用。我们发现,核 PGM1 在 HCC 组织中的低表达与预后不良有关。核 PGM1 是 HCC 患者的一个独立预后因素。此外,核 PGM1 与其他独立危险因素相结合显示出更好的预后价值。核PGM1是一种对HCC患者有用的预后生物标志物。
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Expression and Clinical Significance of Nuclear Phosphoglucomutase-1 in Hepatocellular Carcinoma.

This study aimed to evaluate the predictive values of phosphoglucomutase-1 (PGM1) expression for prognosis in patients with hepatocellular carcinoma (HCC). PGM1 expression was assessed by immunohistochemistry in tissue microarrays. The relationship of PGM1 expression level with pathologic parameters and prognosis values was respectively analyzed by χ 2 test and Cox regression. The accuracy of independent risk factors in predicting prognosis was calculated by receiver operating characteristic curve. HCC patient-derived xenograft models were performed to evaluate the nuclear PGM1 antitumor effect. The results showed that PGM1 expression was low in HCC tissues. Nuclear PGM1 was an independent prognostic factor for overall survival and time to recurrence. Cox regression showed that nuclear PGM1, serum α-fetoprotein, liver cirrhosis, and TNM staging stage were independent risk predictors for HCC. Receiver operating characteristic curve demonstrated that combination of independent predictors had better prognostic value than TNM staging alone. Moreover, patient-derived xenograft models showed antitumor effect of nuclear PGM1. We found that low expression of nuclear PGM1 was detected in HCC tissues and associated with poor prognostic. Nuclear PGM1 was an independent prognostic factor in patients with HCC. Furthermore, nuclear PGM1 combining other independent risk factors showed a better prognostic value. Nuclear PGM1 was a useful prognostic biomarker for patients with HCC.

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来源期刊
Applied Immunohistochemistry & Molecular Morphology
Applied Immunohistochemistry & Molecular Morphology ANATOMY & MORPHOLOGY-MEDICAL LABORATORY TECHNOLOGY
CiteScore
3.20
自引率
0.00%
发文量
153
期刊介绍: ​Applied Immunohistochemistry & Molecular Morphology covers newly developed identification and detection technologies, and their applications in research and diagnosis for the applied immunohistochemist & molecular Morphologist. Official Journal of the International Society for Immunohistochemisty and Molecular Morphology​.
期刊最新文献
Immunohistochemical Investigation of the Proliferative Activity of Odontogenic Cysts and Tumors. Expression of ALKBH5 in Odontogenic Lesions. Expression and Clinical Significance of Nuclear Phosphoglucomutase-1 in Hepatocellular Carcinoma. Expression of B7-H3 and B7-H4 in Gastric Gastrointestinal Stromal Tumors. A Modified Bleaching Method for Multiplex Immunofluorescence Staining of FFPE Tissue Sections.
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