化脓性髋关节置换术两阶段翻修中术中细胞挽救的安全性。

IF 4.3 2区 医学 Q1 INFECTIOUS DISEASES Antibiotics-Basel Pub Date : 2024-09-21 DOI:10.3390/antibiotics13090902
Lara Krüger, André Strahl, Eva Goedecke, Maximilian M Delsmann, Leon-Gordian Leonhardt, Frank Timo Beil, Jan Hubert
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引用次数: 0

摘要

(1) 背景:本研究旨在评估化脓性髋关节置换两阶段翻修术中再植时术中细胞抢救(ICS)的安全性。(2)方法:作为内部质量控制研究的一部分,从再植过程中处理过的 ICS 血液中提取血液培养物,检查可能的细菌负荷(研究组)。由于临床意义不确定的细菌检出率较高,因此还对接受无菌翻修髋关节置换术的患者(对照组)的连续 ICS 样本进行了检查。对微生物样本、患者和手术特征以及随访数据进行了回顾性分析。(3)结果:研究组 12 名患者中有 9 名(75%)和对照组 8 名患者中有 5 名(63%)的 ICS 血液培养呈阳性。两组之间无明显差异(P = 0.642)。未检测到引起假体周围关节感染(PJI)的最初病原体,但细菌谱与皮肤菌群相似,凝固酶阴性葡萄球菌比例较高。没有观察到可能的血流相关感染引起的并发症。总之,检测到的病原体被解释为无临床意义的污染。(4) 结论:再植手术中的 ICS 被认为是优化患者血液管理的安全且值得推荐的程序。
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Safety of Intraoperative Cell Salvage in Two-Stage Revision of Septic Hip Arthroplasties.

(1) Background: The aim of this study was to evaluate the safety of intraoperative cell salvage (ICS) during reimplantation in the two-stage revision of septic hip arthroplasties. (2) Methods: As part of an internal quality control study, blood cultures were taken from the processed ICS blood during reimplantation and examined for possible bacterial load (study group). Due to a high rate of bacterial detection with uncertain clinical significance, consecutive ICS samples were also examined from patients undergoing aseptic revision hip arthroplasty (control group). Microbiological samples, patient and surgical characteristics and the follow-up data were analyzed retrospectively. (3) Results: 9 out of 12 (75%) patients in the study group and 5 out of 8 (63%) patients in the control group had positive ICS blood cultures. There was no significant difference between the groups (p = 0.642). The initial pathogens causing the periprosthetic joint infection (PJI) were not detected, but the bacterial spectrum resembled skin flora, with a high proportion of coagulase-negative staphylococci. No complications due to possible bloodstream-associated infections were observed. In summary, the detected pathogens were interpreted as contamination without clinical significance. (4) Conclusions: ICS in the context of reimplantation was considered a safe and recommendable procedure to optimize patient blood management.

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来源期刊
Antibiotics-Basel
Antibiotics-Basel Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
7.30
自引率
14.60%
发文量
1547
审稿时长
11 weeks
期刊介绍: Antibiotics (ISSN 2079-6382) is an open access, peer reviewed journal on all aspects of antibiotics. Antibiotics is a multi-disciplinary journal encompassing the general fields of biochemistry, chemistry, genetics, microbiology and pharmacology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers.
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