在不同的言语和语言脑成像研究中,没有证据表明口吃患者的语言侧位发生了改变。

IF 4.1 Q1 CLINICAL NEUROLOGY Brain communications Pub Date : 2024-09-13 eCollection Date: 2024-01-01 DOI:10.1093/braincomms/fcae305
Birtan Demirel, Jennifer Chesters, Emily L Connally, Patricia M Gough, David Ward, Peter Howell, Kate E Watkins
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引用次数: 0

摘要

长期以来,对口吃的一种神经生物学解释是 "不完全大脑优势理论",指的是两个大脑半球对手势和言语 "优势 "的竞争,从而导致语言侧化的改变。在口吃患者的大脑成像中发现,在说话过程中,右半球的活动增加,或者在流利度提高时,右半球的活动从右半球转移到左半球,这重新引起了人们对这些观点的兴趣。在此,我们利用口吃儿童和成人以及典型流利说话者(共 119 人)在四种不同的言语和语言任务(公开句子阅读、公开图片描述、隐蔽句子阅读和隐蔽听觉命名)中的功能磁共振成像数据,重新审视了这一理论。我们使用 "统计参数映射"(Statistical Parametric Mapping)中运行的侧向指数工具箱计算了额叶和颞叶的侧向指数。我们还对更特殊的语言区域进行了重复分析,即厣旁(布罗德曼第 44 区)和三角旁(布罗德曼第 45 区)。口吃患者与典型流利者的侧位指数没有差异,贝叶斯分析为零假设(即口吃患者与典型流利者的侧位没有差异)提供了中等程度的支持。口吃患者与典型流利说者中左侧化或非典型右侧化或双侧化的比例没有差异。我们没有发现口吃患者与典型流利说话者相比,语言侧位减少或不同的理论支持。
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No evidence of altered language laterality in people who stutter across different brain imaging studies of speech and language.

A long-standing neurobiological explanation of stuttering is the incomplete cerebral dominance theory, which refers to competition between two hemispheres for 'dominance' over handedness and speech, causing altered language lateralization. Renewed interest in these ideas came from brain imaging findings in people who stutter of increased activity in the right hemisphere during speech production or of shifts in activity from right to left when fluency increased. Here, we revisited this theory using functional MRI data from children and adults who stutter, and typically fluent speakers (119 participants in total) during four different speech and language tasks: overt sentence reading, overt picture description, covert sentence reading and covert auditory naming. Laterality indices were calculated for the frontal and temporal lobes using the laterality index toolbox running in Statistical Parametric Mapping. We also repeated the analyses with more specific language regions, namely the pars opercularis (Brodmann area 44) and pars triangularis (Brodmann area 45). Laterality indices in people who stutter and typically fluent speakers did not differ, and Bayesian analyses provided moderate to anecdotal levels of support for the null hypothesis (i.e. no differences in laterality in people who stutter compared with typically fluent speakers). The proportions of the people who stutter and typically fluent speakers who were left lateralized or had atypical rightward or bilateral lateralization did not differ. We found no support for the theory that language laterality is reduced or differs in people who stutter compared with typically fluent speakers.

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