一项前瞻性临床研究,调查肾移植受者牙周病与慢性肾病进展之间的关系。

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Journal of pharmacy & bioallied sciences Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI:10.4103/jpbs.jpbs_439_24
Pallavi Priya, Sakshi Raina, Manisha Pathak, Subhash Kumar, Parul Chhabra, Vaibhava Raaj, Hiroj Bagde
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引用次数: 0

摘要

背景:牙周病和慢性肾脏病(CKD)都是对公众健康有重大影响的流行病。这项前瞻性临床研究旨在探讨牙周病与肾移植受者慢性肾脏病进展之间的潜在关系:本研究共招募了 150 名患有不同程度牙周病的肾移植受者。进行了牙周基线评估,包括探诊深度、临床附着丧失和探诊出血。在基线时测量估计肾小球滤过率(eGFR),并在 24 个月内定期随访。根据牙周病的严重程度将参与者分成几组,进行比较分析:结果:基线时,轻度牙周病组的平均 eGFR 为 60.5 ± 10.2 mL/min/1.73 m2,中度牙周病组为 58.3 ± 9.8 mL/min/1.73 m2,重度牙周病组为 55.7 ± 8.5 mL/min/1.73 m2。在 24 个月的随访期间,与轻度或中度牙周病患者相比,重度牙周病患者的 eGFR 显著下降(P < 0.05)。此外,重度牙周病患者的 CKD 进展发生率更高,CKD 进展的定义是 eGFR 从基线下降超过 10%:这项前瞻性临床研究表明,严重牙周病与肾移植受者的 CKD 进展之间存在潜在联系。
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A Prospective Clinical Study Investigating the Relationship between Periodontal Disease and the Progression of Chronic Kidney Disease in Renal Transplant Recipients.

Background: Periodontal disease and chronic kidney disease (CKD) are both prevalent conditions with significant implications for public health. This prospective clinical study aimed to explore the potential relationship between periodontal disease and the progression of CKD in renal transplant recipients.

Materials and methods: A total of 150 renal transplant recipients with varying degrees of periodontal disease were enrolled in this study. Baseline periodontal assessments, including probing depth, clinical attachment loss, and bleeding on probing, were conducted. The estimated glomerular filtration rate (eGFR) was measured at baseline and followed up at regular intervals over 24 months. Participants were divided into groups based on the severity of periodontal disease for comparative analysis.

Results: At baseline, the mean eGFR was 60.5 ± 10.2 mL/min/1.73 m2 in the mild periodontal disease group, 58.3 ± 9.8 mL/min/1.73 m2 in the moderate periodontal disease group, and 55.7 ± 8.5 mL/min/1.73 m2 in the severe periodontal disease group. Over the 24-month follow-up period, participants with severe periodontal disease experienced a significant decline in eGFR compared to those with mild or moderate periodontal disease (P < 0.05). In addition, individuals with severe periodontal disease exhibited a higher incidence of CKD progression, defined as a decline in eGFR greater than 10% from baseline.

Conclusion: This prospective clinical study suggests a potential association between severe periodontal disease and the progression of CKD in renal transplant recipients.

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