新型子宫内膜异位症唾液检验的局限性和前景:一项针对德国妇科医疗服务提供者的开放式网络调查研究。

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-09-26 DOI:10.1007/s00404-024-07601-3
Meletios P Nigdelis, Merle Doerk, Stefanie Burghaus, Martin Sillem, Bashar Haj Hamoud, Erich-Franz Solomayer, Gregor Leonhard Olmes
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引用次数: 0

摘要

导言:对子宫内膜异位症唾液 miRNA 特征的描述促使了无创诊断测试的发展。目前,医疗服务提供者对该检测方法的实践仍未掌握。我们通过一项网络调查研究了该测试在实践中的应用情况,目的是了解他们对该测试的看法:我们在 2023 年 11 月至 2024 年 1 月期间进行了一项开放式网络调查研究。我们通过电子邮件两次联系了德国妇科内镜学会(Arbeitsgemeinschaft gynäkologische Endoskopie, AGE)、子宫内膜异位症学会(Arbeitsgemeinschaft Endometriose, AGEM)和子宫内膜异位症研究基金会(Stiftung Endometriose Forschung, SEF)的成员。参与者的数据均已匿名。使用χ2检验或费雪精确检验评估了根据自我报告的该领域专业知识(基础知识、专业知识、专家)所作回答的差异。统计显著性设定为 p 结果:在 190 名受访者中,共有 141 人完整回答了调查问题(> 75% 的问题)。有 21 名医生表示有过测试经验,而大多数参与者至少具备该领域的专业知识(112/141)。就具体问题而言,90% 以上的人认为成本高;近 85% 的人不认为该检验能取代标准诊断工具(组织学、临床检查和超声波检查)。86%的医疗服务提供者支持在青少年中使用该检查。与经验丰富的妇科医生相比,有基础知识的妇科医生对唾液检验的实用性持更积极的态度(费雪精确检验,P 2 检验,P = 0.002):讨论:尽管子宫内膜异位症唾液检测具有良好的前景,但德国医疗服务提供者不会改变目前的做法。尽管如此,经验较少的同事对唾液检测的态度更为积极。
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Limitations and perspectives of the novel salivary test for endometriosis: an open web-based survey study of German gynecologic healthcare providers.

Introduction: The description of a salivary miRNA signature for endometriosis has led to the development of a non-invasive diagnostic test. Current healthcare provider practices regarding the test remain uncaptured. The application of this test in practice was examined in a web-based survey, with the aim to provide their opinions on it.

Methods: We conducted an open web-based survey study between November 2023 and January 2024. Members of the German society of gynecologic endoscopy (Arbeitsgemeinschaft gynäkologische Endoskopie, AGE), society of endometriosis (Arbeitsgemeinschaft Endometriose, AGEM), and the endometriosis research foundation (Stiftung Endometriose Forschung, SEF) were contacted per e-mail twice. Participants' data were anonymized. Differences in responses based on self-reported expertise in the field (basic knowledge, specialized knowledge, expert) were assessed using the χ2-test or Fisher's exact test. Statistical significance was set as p < 0.05.

Results: In total 141 of 190 respondents completely responded to the survey (> 75% of the questions of the survey). Twenty-one physicians reported having experience with the test, while most participants had at least specialized knowledge on the field (112/141). In terms of specific questions, more than 90% found the costs high; almost 85% did not believe that the test replaces standard diagnostic tools (histology, clinical examination, and sonography). Eighty-six providers supported the use of the test in adolescents. Gynecologists with basic knowledge had a more positive attitude compared with more experienced ones in terms of usefulness (Fisher's exact test, p < 0.001). Significant differences were demonstrated between expertise groups regarding (not only) applicability in adolescents (Fisher's exact test, p = 0.004), and using the test for screening purposes (χ2-test, p = 0.002).

Discussion: Despite the promising benefits of a salivary test for endometriosis, German healthcare providers would not change current practices. Nevertheless, less experienced colleagues were more positive towards the test.

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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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