作为益生菌补充剂的丁酸菌:对肥胖症小鼠模型的新陈代谢和行为调节产生有益影响。

IF 3 4区 医学 Q2 MICROBIOLOGY Beneficial microbes Pub Date : 2024-09-23 DOI:10.1163/18762891-bja00040
A M Garcia-Serrano, C Skoug, U Axling, E R Korhonen, C Teixeira, I L Ahrén, I Mukhopadhya, N Boteva, J Martin, K Scott, S Gratz, K G Stenkula, C Holm, J M N Duarte
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引用次数: 0

摘要

肥胖是心血管代谢疾病和神经系统疾病的危险因素。肠道微生物群对肥胖情况下肠道-大脑轴的失调所起的作用已得到承认,特别是通过短链脂肪酸(SCFAs)的生理调节作用。因此,人们采用益生菌干预和服用 SCFAs 来减轻代谢性疾病和神经系统疾病的症状。我们研究了 Lachnospiraceae 家族的四种产丁酸的细菌对饮食诱发肥胖小鼠模型中代谢综合征的发展和行为改变的影响。雄性小鼠以高脂肪饮食(HFD)或成分匹配的对照饮食喂养 2 个月,每隔一天给喂养 HFD 的小鼠灌胃一次细菌培养物或培养基。通过一系列代谢和行为测试对小鼠进行评估,并使用葡聚糖示踪剂测定通过肠道屏障和血脑屏障的通量。给药的 Coprococcus 属细菌之一能产生丁酸盐和甲酸盐,在一定程度上能防止肥胖症及其并发症的发生。不过,这项研究的结果不足以证明所测试的细菌对大脑健康有益。没有一种细菌能调节肠道或血脑屏障的渗透性。我们的研究结果表明,漆树科细菌对健康有益,并鼓励进一步探索将其用作益生菌。
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Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behaviour in an obesity mouse model.

Obesity is a risk factor for cardio-metabolic and neurological disease. The contribution of gut microbiota to derangements of the gut-brain axis in the context of obesity has been acknowledged, particularly through physiology modulation by short-chain fatty acids (SCFAs). Thus, probiotic interventions and administration of SCFAs have been employed with the purpose of alleviating symptoms in both metabolic and neurological disease. We investigated the effects of four butyrate-producing bacteria from the Lachnospiraceae family on the development of metabolic syndrome and behavioural alterations in a mouse model of diet-induced obesity. Male mice were fed either a high-fat diet (HFD) or an ingredient-matched control diet for 2 months, and bacteria cultures or culture medium were given by gavage to HFD-fed mice every second day. Mice were assessed through a battery of metabolic and behaviour tests, and fluxes through the gut barrier and blood-brain barrier were determined using Dextran-based tracers. One of the administered bacteria from the Coprococcus genus, which produces butyrate and formate, afforded some degree of protection against the development of obesity and its complications. Results from this study, however, are insufficient to support brain health benefits of the bacteria tested. None of the bacteria modulated permeability through the gut or blood-brain barriers. Our results suggest health benefits of a bacteria from Lachnospiraceae family, and encourage further exploration of its use as probiotic.

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来源期刊
Beneficial microbes
Beneficial microbes MICROBIOLOGY-NUTRITION & DIETETICS
CiteScore
7.90
自引率
1.90%
发文量
53
审稿时长
>12 weeks
期刊介绍: Beneficial Microbes is a peer-reviewed scientific journal with a specific area of focus: the promotion of the science of microbes beneficial to the health and wellbeing of man and animal. The journal contains original research papers and critical reviews in all areas dealing with beneficial microbes in both the small and large intestine, together with opinions, a calendar of forthcoming beneficial microbes-related events and book reviews. The journal takes a multidisciplinary approach and focuses on a broad spectrum of issues, including safety aspects of pro- & prebiotics, regulatory aspects, mechanisms of action, health benefits for the host, optimal production processes, screening methods, (meta)genomics, proteomics and metabolomics, host and bacterial physiology, application, and role in health and disease in man and animal. Beneficial Microbes is intended to serve the needs of researchers and professionals from the scientific community and industry, as well as those of policy makers and regulators. The journal will have five major sections: * Food, nutrition and health * Animal nutrition * Processing and application * Regulatory & safety aspects * Medical & health applications In these sections, topics dealt with by Beneficial Microbes include: * Worldwide safety and regulatory issues * Human and animal nutrition and health effects * Latest discoveries in mechanistic studies and screening methods to unravel mode of action * Host physiology related to allergy, inflammation, obesity, etc. * Trends in application of (meta)genomics, proteomics and metabolomics * New developments in how processing optimizes pro- & prebiotics for application * Bacterial physiology related to health benefits
期刊最新文献
The prebiotic landscape: history, health and physiological benefits, and regulatory challenges - an IPA perspective part 1. Probiotic viability in the gastrointestinal tract in a randomised placebo controlled trial: combining molecular biology and novel cultivation techniques. Deciphering the mechanisms of action underlying probiotic properties of Shouchella clausii by a functional genomics approach. Bacillus subtilis DE111 partially reverses endothelial dysfunction in western-diet fed mice. Deciphering the role of probiotics in mental health: a systematic literature review of psychobiotics.
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