抑郁症相关心血管疾病中内皮功能障碍、炎症和糖皮质激素抵抗的汇合。

IF 2.9 4区 医学 Q3 IMMUNOLOGY BMC Immunology Pub Date : 2024-09-27 DOI:10.1186/s12865-024-00653-9
Zachary Hage, Miguel M Madeira, Dimitris Koliatsis, Stella E Tsirka
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引用次数: 0

摘要

重度抑郁症(抑郁症)与 HPA 轴功能失调、慢性炎症和心血管疾病有着广泛的联系。虽然对前两者进行了深入研究,但抑郁症与心血管疾病之间的机理联系尚不清楚。作为血管稳态、血管病理和免疫活动的主要介质,内皮细胞是连接这些疾病的重要角色。炎症加剧和糖皮质激素功能是探讨内皮细胞对多发性硬化症反应的重要课题。几种细胞类型的糖皮质激素抗性会强烈促进炎症信号转导,导致许多疾病的严重程度恶化。然而,人们很少从糖皮质激素信号传导和抵抗的角度来考虑慢性应激和抑郁症中的内皮健康和炎症问题。在这篇综述中,我们旨在讨论:(1) 抑郁症的内皮功能障碍;(2) 抑郁症的炎症;(3) 抑郁症的一般糖皮质激素抵抗;(4) 抑郁症合并炎症性疾病的内皮糖皮质激素抵抗。我们将首先分别描述抑郁症中的血管病理学、炎症和糖皮质激素抵抗,然后描述它们在抑郁症相关疾病中的潜在相互作用。最后,我们将假设内皮细胞的糖皮质激素抵抗可能导致抑郁症患者血管疾病状态的潜在机制。总之,内皮细胞-糖皮质激素信号传导可能在连接抑郁症和血管病理学方面发挥重要作用,值得进一步研究。
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Convergence of endothelial dysfunction, inflammation and glucocorticoid resistance in depression-related cardiovascular diseases.

Major Depressive Disorder, or depression, has been extensively linked to dysregulated HPA axis function, chronic inflammation and cardiovascular diseases. While the former two have been studied in depth, the mechanistic connection between depression and cardiovascular disease is unclear. As major mediators of vascular homeostasis, vascular pathology and immune activity, endothelial cells represent an important player connecting the diseases. Exaggerated inflammation and glucocorticoid function are important topics to explore in the endothelial response to MDD. Glucocorticoid resistance in several cell types strongly promotes inflammatory signaling and results in worsened severity in many diseases. However, endothelial health and inflammation in chronic stress and depression are rarely considered from the perspective of glucocorticoid signaling and resistance. In this review, we aim to discuss (1) endothelial dysfunction in depression, (2) inflammation in depression, (3) general glucocorticoid resistance in depression and (4) endothelial glucocorticoid resistance in depression co-morbid inflammatory diseases. We will first describe vascular pathology, inflammation and glucocorticoid resistance separately in depression and then describe their potential interactions with one another in depression-relevant diseases. Lastly, we will hypothesize potential mechanisms by which glucocorticoid resistance in endothelial cells may contribute to vascular disease states in depressed people. Overall, endothelial-glucocorticoid signaling may play an important role in connecting depression and vascular pathology and warrants further study.

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来源期刊
BMC Immunology
BMC Immunology 医学-免疫学
CiteScore
5.50
自引率
0.00%
发文量
54
审稿时长
1 months
期刊介绍: BMC Immunology is an open access journal publishing original peer-reviewed research articles in molecular, cellular, tissue-level, organismal, functional, and developmental aspects of the immune system as well as clinical studies and animal models of human diseases.
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