记住缺氧:揭示短暂缺氧对 IFN 信号转导和乳腺癌进展的长期影响。

IF 12.5 1区 医学 Q1 ONCOLOGY Cancer research Pub Date : 2024-10-01 DOI:10.1158/0008-5472.CAN-24-2407
Stephen Connor Purdy, Heide L Ford
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引用次数: 0

摘要

90%的实体瘤都存在缺氧现象,而且缺氧与肿瘤转移倾向的增加密切相关。缺氧主要通过诱导 HIF 介导的转录来诱导肿瘤进展,导致肿瘤细胞新陈代谢的改变以及迁移和侵袭的增加。缺氧还会导致肿瘤微环境(TME)发生一系列变化。虽然许多研究都探讨了缺氧对肿瘤细胞和相关肿瘤微环境的直接影响,但关注氧气短暂减少的长期后果的研究却少得多。在本期《癌症研究》(Cancer Research)杂志上,Iriondo及其同事研究了短期暴露于缺氧是否会导致乳腺癌的 "缺氧记忆"。作者利用已建立的细胞系和循环肿瘤细胞系证明,这些细胞具有缺氧记忆,能维持 IFN 信号转导和抗原递呈 (AP) 通路的下调,通过改变肿瘤细胞和 TME 促进肿瘤进展。作者进一步表明,经历过缺氧的细胞在体内会维持 IFN 信号的下调,并且更具侵袭性。他们确定,缺氧记忆和 IFN 信号的减少可以通过组蛋白去乙酰化酶抑制剂恩替诺司他逆转,这为逆转缺氧诱导的 IFN 信号抑制提供了一种潜在的方法。由于IFN信号的抑制有可能同时影响肿瘤细胞和TME,因此确定一种抑制缺氧下游IFN信号长期抑制的策略可能被证明是针对肿瘤进展的一种有效手段。见 Iriondo 等人的相关文章,第 3141 页。
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Remembering Hypoxia: Uncovering the Long-Term Effects of Transient Oxygen Deprivation on IFN Signaling and Progression of Breast Cancer.

Hypoxia occurs in 90% of solid tumors and is strongly associated with an increased propensity for metastasis. Hypoxia induces tumor progression largely through inducing HIF-mediated transcription, resulting in alterations to tumor cell metabolism, as well as increases in migration and invasion. Hypoxia also results in a myriad of changes to the tumor microenvironment (TME). While many studies have examined the immediate effects of hypoxia on tumor cells and the associated TME, far fewer have focused on the long-term consequences of transient reductions in oxygen. In this issue of Cancer Research, Iriondo and colleagues examined whether short-term exposure to hypoxia leads to a "hypoxic memory" in the context of breast cancer. The authors used established cell lines and circulating tumor cell lines to demonstrate that these cells harbor a hypoxic memory that sustains downregulation of IFN signaling and antigen presentation (AP) pathways that contribute to tumor progression via alterations to tumor cells and the TME. The authors further showed that cells that have experienced hypoxia maintain the reduction in IFN signaling in vivo and are more aggressive. They determined that the hypoxic memory and reduction of IFN signaling can be reversed with a histone deacetylase inhibitor, entinostat, providing a potential means to reverse hypoxia-induced suppression of IFN signaling. As suppression of IFN signaling has the potential to influence both tumor cells and the TME, the identification of a strategy to inhibit long-term suppression of IFN signaling downstream of hypoxia could prove to be an effective means to target tumor progression. See related article by Iriondo et al., p. 3141.

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来源期刊
Cancer research
Cancer research 医学-肿瘤学
CiteScore
16.10
自引率
0.90%
发文量
7677
审稿时长
2.5 months
期刊介绍: Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research. With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445. Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.
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