大肠癌筛查的下一个前沿：基于血液的检测

IF 12.5 1区医学 Q1 ONCOLOGY Cancer research Pub Date : 2024-10-01 DOI:10.1158/0008-5472.CAN-24-1620

Christian Rolfo, Alessandro Russo

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引用次数: 0

摘要

结肠直肠癌与全世界范围内的大量发病率和死亡率有关。通过已获批准的筛查测试可以检测出早期结直肠癌，但总体坚持率很低。采用有效的非侵入性方法可以提高筛查率，避免大量死亡。使用液体活检有可能实现无创早期癌症检测。在本期《癌症研究》（Cancer Research）杂志上，Cao及其同事报告了一种新型多维片段组学检测方法（名为FRAGTECT），用于检测循环中无细胞DNA中的结直肠癌，结果令人鼓舞。请参见 Cao 等人的相关文章，第 3286 页。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Next Frontier for Colorectal Cancer Screening: Blood-Based Tests.

Colorectal cancer is associated with substantial morbidity and mortality worldwide. Detection of early colorectal cancer is possible through approved screening tests but overall adherence is quite low. Implementation of effective noninvasive options could increase screening uptake and prevent a significant number of deaths. Noninvasive early cancer detection can potentially be achieved using a liquid biopsy. In this issue of Cancer Research, Cao and colleagues report on a novel multidimensional fragmentomics assay, named FRAGTECT, for colorectal cancer detection in circulating cell-free DNA with promising results. See related article by Cao et al., p. 3286.

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来源期刊

Cancer research 医学-肿瘤学

CiteScore

16.10

自引率

0.90%

发文量

7677

审稿时长

2.5 months

期刊介绍： Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research. With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445. Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.