头颈部鳞状细胞癌中的葡萄糖代谢和葡萄糖转运体

IF 1.8 4区医学 Q3 ONCOLOGY Cancer Investigation Pub Date : 2024-11-01 Epub Date: 2024-09-26 DOI:10.1080/07357907.2024.2407424

Yanyan Ye, Zaizai Cao

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引用次数: 0

摘要

头颈部鳞状细胞癌在全球恶性肿瘤发病率中排名第七，尽管治疗手段不断进步，但死亡率却居高不下。葡萄糖通过沃伯格效应在癌症代谢中起着关键作用，它通过葡萄糖转运体，特别是 GLUT 蛋白进入细胞。葡萄糖代谢中的糖酵解、有氧氧化和磷酸戊糖途径对 HNSCC 的进展有重大影响。HNSCC 的葡萄糖代谢酶和 GLUT 蛋白表达升高，与预后相关。HNSCC 的异质性产生了不同的代谢特征，并受到 HPV 状态和疾病分期等因素的影响。本综述强调了葡萄糖代谢在 HNSCC 中作为治疗靶点和癌症成像示踪剂的作用和潜力。

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Glucose Metabolism and Glucose Transporters in Head and Neck Squamous Cell Carcinoma.

Head and neck squamous cell carcinoma ranks seventh globally in malignancy prevalence, with persistent high mortality rates despite treatment advancements. Glucose, pivotal in cancer metabolism via the Warburg effect, enters cells via glucose transporters, notably GLUT proteins. Glycolysis, aerobic oxidation, and the pentose phosphate pathway in glucose metabolism significantly impact HNSCC progression. HNSCC exhibits elevated expression of glucose metabolism enzymes and GLUT proteins, correlating with prognosis. Heterogeneity in HNSCC yields varied metabolic profiles, influenced by factors like HPV status and disease stage. This review highlights glucose metabolism's role and potential as therapeutic targets and cancer imaging tracers in HNSCC.

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.