Hong Xu, Chen Zang, Fangbo Zhang, Jixiang Tian, Hua Li, Shihuan Tang, Guohua Wang
{"title":"将创新的流变分析方法应用于三七总皂苷眼用凝胶的配方优化。","authors":"Hong Xu, Chen Zang, Fangbo Zhang, Jixiang Tian, Hua Li, Shihuan Tang, Guohua Wang","doi":"10.1080/09205063.2024.2406632","DOIUrl":null,"url":null,"abstract":"<p><p>Emphasizing the viscoelasticity of ophthalmic gels is crucial for understanding the residence time, structure, and stability of hydrogels. This study primarily aimed to propose an innovative rheology analysis method for ophthalmic gels, considering complex eye movements. This method was applied to select ophthalmic gels with favorable rheological characteristics. Additionally, the physical characteristics and <i>in vitro</i> release of the selected <i>Panax notoginseng</i> total saponins (PNS) gel were demonstrated. The selected PNS gel significantly increased the activities of SOD and decreased intracellular levels of MDA, TNF-α, and IL-1β in H<sub>2</sub>O<sub>2</sub>-treated ARPE-19 cells. Finally, the optimal formulation was selected as a suitable platform for ophthalmic delivery and was shown to significantly rescue ARPE-19 cells from oxidative cellular damage.</p>","PeriodicalId":15195,"journal":{"name":"Journal of Biomaterials Science, Polymer Edition","volume":" ","pages":"1-19"},"PeriodicalIF":3.6000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An innovative rheology analysis method applies to the formulation optimization of Panax notoginseng total saponins ocular gel.\",\"authors\":\"Hong Xu, Chen Zang, Fangbo Zhang, Jixiang Tian, Hua Li, Shihuan Tang, Guohua Wang\",\"doi\":\"10.1080/09205063.2024.2406632\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Emphasizing the viscoelasticity of ophthalmic gels is crucial for understanding the residence time, structure, and stability of hydrogels. This study primarily aimed to propose an innovative rheology analysis method for ophthalmic gels, considering complex eye movements. This method was applied to select ophthalmic gels with favorable rheological characteristics. Additionally, the physical characteristics and <i>in vitro</i> release of the selected <i>Panax notoginseng</i> total saponins (PNS) gel were demonstrated. The selected PNS gel significantly increased the activities of SOD and decreased intracellular levels of MDA, TNF-α, and IL-1β in H<sub>2</sub>O<sub>2</sub>-treated ARPE-19 cells. Finally, the optimal formulation was selected as a suitable platform for ophthalmic delivery and was shown to significantly rescue ARPE-19 cells from oxidative cellular damage.</p>\",\"PeriodicalId\":15195,\"journal\":{\"name\":\"Journal of Biomaterials Science, Polymer Edition\",\"volume\":\" \",\"pages\":\"1-19\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomaterials Science, Polymer Edition\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1080/09205063.2024.2406632\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials Science, Polymer Edition","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/09205063.2024.2406632","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
An innovative rheology analysis method applies to the formulation optimization of Panax notoginseng total saponins ocular gel.
Emphasizing the viscoelasticity of ophthalmic gels is crucial for understanding the residence time, structure, and stability of hydrogels. This study primarily aimed to propose an innovative rheology analysis method for ophthalmic gels, considering complex eye movements. This method was applied to select ophthalmic gels with favorable rheological characteristics. Additionally, the physical characteristics and in vitro release of the selected Panax notoginseng total saponins (PNS) gel were demonstrated. The selected PNS gel significantly increased the activities of SOD and decreased intracellular levels of MDA, TNF-α, and IL-1β in H2O2-treated ARPE-19 cells. Finally, the optimal formulation was selected as a suitable platform for ophthalmic delivery and was shown to significantly rescue ARPE-19 cells from oxidative cellular damage.
期刊介绍：
The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels.
The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
