游离血管化腓骨移植物在治疗前臂大面积骨骼缺损中的疗效。

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Journal of Personalized Medicine Pub Date : 2024-09-14 DOI:10.3390/jpm14090973
Panagiotis Konstantinou, Lazaros Kostretzis, Athina Zacharoula Ditsiou, Ioannis Samaras, Pericles Papadopoulos, Konstantinos Ditsios
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引用次数: 0

摘要

介绍:重建上肢长骨缺损,尤其是桡骨和尺骨,是一项重大挑战。这些缺损由创伤、肿瘤、感染或先天畸形造成,需要精确的手术干预才能恢复功能。传统的无血管自体骨移植物存在吸收和生物活性有限等局限性。为了应对这些挑战,人们开发了游离血管化腓骨移植物(FVFGs),通过提供营养和结构支持来促进恢复,尤其是在大面积缺损或血管受损的情况下:这项回顾性研究回顾了 2008 年 1 月至 2019 年 1 月在我院接受 FVFGs 治疗的前臂骨骼重大缺损患者。研究对象包括因外伤、肿瘤切除或骨折不愈合导致桡骨或尺骨缺损超过 8 厘米的患者。分析了有关人口统计学、临床细节、手术技术和结果的数据,包括移植物愈合时间、并发症、活动范围以及手臂、肩部和手部残疾(DASH)评分:共纳入八名患者,平均年龄为 27.6 岁,平均缺损长度为 9.8 厘米。所有患者均在平均 4 个月内实现移植物结合,无肿瘤复发或重大并发症。功能结果显示,平均前臂前伸56.9度,上举52.5度,平均DASH评分17.7分:FVFG是治疗复杂前臂骨缺损的一种安全有效的技术,具有较高的骨结合率和良好的功能效果。应将其作为治疗前臂大面积骨骼缺损的主要选择。
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Outcomes of Free Vascularized Fibular Grafts in Treating Massive Forearm Skeletal Defects.

Introduction: Reconstructing long bone defects in the upper limbs, particularly the radius and ulna, poses significant challenges. These defects, resulting from trauma, tumors, infections, or congenital anomalies, require precise surgical intervention for functional restoration. Traditional non-vascularized autogenous bone grafts have limitations, such as resorption and limited biological activity. To address these challenges, free vascularized fibular grafts (FVFGs) have been developed, offering enhanced recovery by supplying nutrients and structural support, particularly in large defects or compromised vascularity.

Materials and methods: This retrospective study reviewed patients with significant forearm skeletal defects treated with FVFGs at our institution from January 2008 to January 2019. Included were patients with radius or ulna defects exceeding 8 cm due to trauma, tumor excision, or non-union fractures. Data on demographics, clinical details, surgical techniques, and outcomes-including graft union time, complications, range of motion, and the disabilities of the arm, shoulder and hand (DASH) scores-were analyzed.

Results: Eight patients, with a mean age of 27.6 years and an average defect length of 9.8 cm, were included. All patients achieved graft union within an average of 4 months, with no tumor recurrence or significant complications. Functional outcomes showed mean forearm pronation of 56.9 degrees, supination of 52.5 degrees, and a mean DASH score of 17.7.

Conclusions: FVFG is a safe and effective technique for managing complex forearm bone defects, providing high union rates and good functional outcomes. It should be considered a primary option for large forearm skeletal defects.

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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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