肿瘤内人工关节置换中的非骨水泥定制空心柄--保护儿童相邻关节的良机?

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES Journal of Personalized Medicine Pub Date : 2024-08-29 DOI:10.3390/jpm14090919
Recep Öztürk, Arne Streitbürger, Jendrik Hardes, Gregor Hauschild, Wiebke K Guder, Lars Erik Podleska, Markus Nottrott, Nina Myline Engel
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引用次数: 0

摘要

本研究旨在回顾性分析2017年至2023年期间,13名患者(平均年龄9.6岁)因骨肉瘤采用定制的非骨水泥短茎设计(空心茎),并可选择外翻瓣进行肿瘤假体置换,从而保留邻近关节的病例的随访结果。重建的肿瘤假体包括股骨近端(n = 6)、股骨闰端(n = 4)、胫骨闰端(n = 2)和肱骨近端(n = 1)。在10个巨型假体中,空心体用于远端,1个用于近端,2个同时用于近端和远端。带凸缘的假体柄距关节的平均距离为 6 厘米,不带凸缘的假体柄距关节的平均距离为 11.8 厘米。在平均 34 个月的随访中,未发现无菌性松动或深度感染。除一例胫骨髓楔假体需要翻修外,所有病例均骨结合良好,所有下肢病例均能承受全部重量而无疼痛。在骨切除后剩余骨量不足以进行标准骨干植入的情况下,采用患者特异性短空心骨干设计进行重建似乎是保护健康关节的良好替代方案,而且假体存活率高,短期随访中的翻修率低。
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Uncemented Customized Hollow Stems in Tumor Endoprosthetic Replacement-A Good Opportunity to Protect the Adjacent Joint in Children?

This study aimed to retrospectively analyze the follow-up results of cases in which the adjacent joint was preserved using a custom-made uncemented short-stem design (hollow stem) with optional external flanches in tumor endoprosthetic replacement due to bone sarcomas in 13 patients (with an average age of 9.6 years) between 2017 and 2023. Reconstructions were proximal femur (n = 6), intercalary femur (n = 4), intercalary tibia (n = 2), and proximal humerus (n = 1) tumor prostheses. The hollow body was used distally in 10 of the megaprotheses, proximally in 1, and both proximally and distally in 2 of them. The average distance from the joints was 6 cm in stems with flanches and 11.8 cm in stems without flanches. No aseptic loosening or deep infection was observed during an average follow-up of 34 months. Except for one case with a tibial intercalary prosthesis that needed a revision, all cases were well osteointegrated and all lower extremity cases could bear full weight without pain. In cases where the remaining bone stock after bone resection is insufficient for a standard stem implantation, reconstruction with a patient-specific short hollow-stem design appears to be a good alternative to protect healthy joints with high prosthesis survival and low revision rates in the short-term follow-up.

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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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