模仿 CASPR2 抗体相关疾病的多系统萎缩:一份病例报告。

IF 2.3 Q3 CLINICAL NEUROLOGY Neurodegenerative disease management Pub Date : 2024-01-01 Epub Date: 2024-09-25 DOI:10.1080/17582024.2024.2388506
Xiaoli Chen, Li Feng, Jing Li, Hong Jiang
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引用次数: 0

摘要

目的:多系统萎缩(MSA)和 CASPR2 抗体相关疾病各有特点:一名 58 岁的妇女因步态不协调和言语不清就诊 26 个月。她的血清中抗 CASPR2 抗体呈阳性,核磁共振成像显示脑干和小脑萎缩。她进行了三次血浆置换(PE),并接受了大剂量皮质类固醇治疗,但效果不明显。重复经颅磁刺激后,她的自主神经功能障碍有所改善。最终,她被诊断为MSA-小脑表型(MSA-C):结论:随着神经元抗体检测工具的增多,医生需要意识到抗体可能会伴随其他疾病。本报告强调了神经元抗体检测的可用性和广泛性所带来的现代困境。
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Multiple system atrophy mimics CASPR2 antibody-associated disease: a case report.

Aim: Multiple system atrophy (MSA) and CASPR2 antibody-associated disease bear their own characteristics.Case presentation: A 58-year-old woman presented with a 26 months history of uncoordinated gait and slurred speech. Her serum was positive for anti-CASPR2 antibodies, and MRI revealed atrophy of the brainstem and cerebellum. She underwent three plasma exchanges (PE) and received high doses of corticosteroids without any apparent effect. Her autonomic dysfunction improved after repetitive transcranial magnetic stimulation. Eventually, a diagnosis of MSA-cerebellar phenotype(MSA-C) was made.Conclusion: With increased availability of tools for neuron antibody detection, physicians need to be aware of the possibility that antibodies may accompany other diseases. This report underscores the modern dilemmas caused by available and extensive neuron antibody testing.

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