天麻素能改善长期暴露于噪音环境造成的学习和记忆障碍

IF 1.3 4区 医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Noise & Health Pub Date : 2024-07-01 Epub Date: 2024-09-30 DOI:10.4103/nah.nah_76_24
Lin Wu, Ying Liu, Hu Zhou, Zhenzhen Cao, Jianyun Yu
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引用次数: 0

摘要

发育中的大脑在幼年时期长期暴露于噪音中会受到严重影响,导致学习和记忆障碍等功能紊乱。天麻素(GAS)是一种天然有机化合物,是从天麻根茎中提取的酚苷。在临床上,天麻素被广泛用于治疗神经系统疾病。本研究旨在探讨天麻素对噪音暴露引起的学习和记忆障碍的影响和机制。将年龄为 21 天的大鼠暴露在 90 dB 的噪音环境中 4 周,并将其分为噪音组、噪音 + GAS 组和对照组,以建立噪音暴露模型。噪音暴露处理后,通过Y迷宫和Morris水迷宫评估GAS对大鼠记忆力的改善作用。利用酶联免疫吸附法测定 GAS 对噪声暴露大鼠海马组织中神经递质水平的影响。Western 印迹法用于检测神经营养因子的蛋白水平。经 GAS 治疗后,噪声暴露大鼠海马组织中的空间记忆明显改善,关键神经递质(去甲肾上腺素、多巴胺和血清素)和神经营养因子(神经营养素-3 和脑源性神经营养因子)的水平也有所提高。这些变化与认知功能的增强相关,表明 GAS 对噪声引起的认知障碍具有神经保护作用。这项研究支持 GAS 通过调节神经递质分泌和提高神经营养因子的表达水平来治疗噪声引起的学习和记忆损伤的潜力。这些发现为治疗噪声暴露引起的认知障碍提供了潜在的治疗途径。
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Gastrodin Ameliorates Learning and Memory Impairments Caused by Long-Term Noise Exposure.

The developing brain is significantly affected by long-term exposure to noise at an early age, leading to functional disorders such as learning and memory impairments. Gastrodin (GAS), a natural organic compound, is an extraction of phenolic glycoside from the rhizome of Gastrodia elata. Clinically, GAS is extensively utilised for the treatment of neurological disorders. This study aimed to explore the effect and mechanism of GAS on noise exposure-induced learning and memory impairments. Rats aged 21 days were exposed to a 90 dB noise environment for 4 weeks and divided into the noise group, the noise + GAS group, and the control group to establish a noise exposure model. After noise exposure treatment, the improvement effect of GAS on the memory of rats was evaluated by Y-maze and Morris water maze. Enzyme-linked immunosorbent assay was utilised to determine the effect of GAS on neurotransmitter levels in the hippocampal tissue of noise-exposed rats. Western blot was applied for the detection of the protein levels of neurotrophic factors. The GAS treatment significantly improved spatial memory and increased the levels of key neurotransmitters (norepinephrine, dopamine and serotonin) and neurotrophic factors (neurotrophin-3 and brain-derived neurotrophic factor) in the hippocampal tissues of noise-exposed rats. These alterations correlate with enhanced cognitive functions, suggesting a neuroprotective effect of GAS against noise-induced cognitive impairments. This study supports the potential of GAS to treat noise-induced learning and memory impairments by modulating neurotransmitter secretion and enhancing the expression levels of neurotrophic factors. These findings offer potential therapeutic avenues for cognitive impairments induced by noise exposure.

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来源期刊
Noise & Health
Noise & Health AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
CiteScore
2.10
自引率
14.30%
发文量
27
审稿时长
6-12 weeks
期刊介绍: Noise and Health is the only International Journal devoted to research on all aspects of noise and its effects on human health. An inter-disciplinary journal for all professions concerned with auditory and non-auditory effects of occupational, environmental, and leisure noise. It aims to provide a forum for presentation of novel research material on a broad range of topics associated with noise pollution, its control and its detrimental effects on hearing and health. It will cover issues from basic experimental science through clinical evaluation and management, technical aspects of noise reduction systems and solutions to environmental issues relating to social and public health policy.
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