Yan-ling Liu , Yan-gang Cao , Ya-juan Zheng , Ying Niu , Lan Chen , Xu Chen , Xin-yi Ma , Xiang-da Li , Xiao-ke Zheng , Wei-sheng Feng
{"title":"利用小分子精确识别技术，有针对性地从西洋蒽（L. Hoffm.）根中分离木质素。","authors":"Yan-ling Liu , Yan-gang Cao , Ya-juan Zheng , Ying Niu , Lan Chen , Xu Chen , Xin-yi Ma , Xiang-da Li , Xiao-ke Zheng , Wei-sheng Feng","doi":"10.1016/j.phytochem.2024.114293","DOIUrl":null,"url":null,"abstract":"<div><div>Five undescribed lignans (<strong>1</strong>–<strong>5</strong>), along with sixteen known lignans (<strong>6</strong>–<strong>21</strong>), were isolated from the roots of <em>Anthriscus sylvestris</em> using small molecule accurate recognition technology (SMART). The structures of the isolated compounds were determined by comprehensive spectroscopic analyses, and the absolute configurations of compounds <strong>3</strong>–<strong>5</strong> were elucidated by comparison of their calculated and experimental ECD spectra. Compounds <strong>5</strong>, <strong>14</strong>−<strong>15</strong>, <strong>19</strong>, and <strong>21</strong> exhibited significantly inhibitory effects against hypoxia-stimulated abnormal proliferation of pulmonary arterial smooth muscle cells (PASMCs). Moreover, compounds <strong>5</strong>, <strong>14</strong>−<strong>15</strong>, <strong>19</strong>, and <strong>21</strong> can significantly restore expression of expression of PASMCs proliferation-related protein, including <em>α</em>-SMA, PCNA, P27, and CyclinD3, which are closely related to cell proliferation.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"229 ","pages":"Article 114293"},"PeriodicalIF":3.2000,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeted isolation of lignans from the roots of Anthriscus sylvestris (L.) Hoffm. by small molecule accurate recognition technology\",\"authors\":\"Yan-ling Liu , Yan-gang Cao , Ya-juan Zheng , Ying Niu , Lan Chen , Xu Chen , Xin-yi Ma , Xiang-da Li , Xiao-ke Zheng , Wei-sheng Feng\",\"doi\":\"10.1016/j.phytochem.2024.114293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Five undescribed lignans (<strong>1</strong>–<strong>5</strong>), along with sixteen known lignans (<strong>6</strong>–<strong>21</strong>), were isolated from the roots of <em>Anthriscus sylvestris</em> using small molecule accurate recognition technology (SMART). The structures of the isolated compounds were determined by comprehensive spectroscopic analyses, and the absolute configurations of compounds <strong>3</strong>–<strong>5</strong> were elucidated by comparison of their calculated and experimental ECD spectra. Compounds <strong>5</strong>, <strong>14</strong>−<strong>15</strong>, <strong>19</strong>, and <strong>21</strong> exhibited significantly inhibitory effects against hypoxia-stimulated abnormal proliferation of pulmonary arterial smooth muscle cells (PASMCs). Moreover, compounds <strong>5</strong>, <strong>14</strong>−<strong>15</strong>, <strong>19</strong>, and <strong>21</strong> can significantly restore expression of expression of PASMCs proliferation-related protein, including <em>α</em>-SMA, PCNA, P27, and CyclinD3, which are closely related to cell proliferation.</div></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":\"229 \",\"pages\":\"Article 114293\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224003303\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224003303","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Targeted isolation of lignans from the roots of Anthriscus sylvestris (L.) Hoffm. by small molecule accurate recognition technology
Five undescribed lignans (1–5), along with sixteen known lignans (6–21), were isolated from the roots of Anthriscus sylvestris using small molecule accurate recognition technology (SMART). The structures of the isolated compounds were determined by comprehensive spectroscopic analyses, and the absolute configurations of compounds 3–5 were elucidated by comparison of their calculated and experimental ECD spectra. Compounds 5, 14−15, 19, and 21 exhibited significantly inhibitory effects against hypoxia-stimulated abnormal proliferation of pulmonary arterial smooth muscle cells (PASMCs). Moreover, compounds 5, 14−15, 19, and 21 can significantly restore expression of expression of PASMCs proliferation-related protein, including α-SMA, PCNA, P27, and CyclinD3, which are closely related to cell proliferation.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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