{"title":"噬菌体 HTH 调节器的双重作用。","authors":"Zacharie Morneau, Sylvain Moineau","doi":"10.1016/j.tim.2024.09.005","DOIUrl":null,"url":null,"abstract":"<p><p>Bacteriophages use anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems. The expression of Acr is regulated by anti-CRISPR-associated (Aca) proteins, which are helix-turn-helix (HTH) repressors that bind DNA. Recently, Birkholz et al. discovered that an Aca can also repress Acr expression by binding RNA, revealing a new function for HTH repressors.</p>","PeriodicalId":23275,"journal":{"name":"Trends in Microbiology","volume":" ","pages":"1037-1038"},"PeriodicalIF":14.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The double play of a phage HTH regulator.\",\"authors\":\"Zacharie Morneau, Sylvain Moineau\",\"doi\":\"10.1016/j.tim.2024.09.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Bacteriophages use anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems. The expression of Acr is regulated by anti-CRISPR-associated (Aca) proteins, which are helix-turn-helix (HTH) repressors that bind DNA. Recently, Birkholz et al. discovered that an Aca can also repress Acr expression by binding RNA, revealing a new function for HTH repressors.</p>\",\"PeriodicalId\":23275,\"journal\":{\"name\":\"Trends in Microbiology\",\"volume\":\" \",\"pages\":\"1037-1038\"},\"PeriodicalIF\":14.0000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tim.2024.09.005\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tim.2024.09.005","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/25 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Bacteriophages use anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems. The expression of Acr is regulated by anti-CRISPR-associated (Aca) proteins, which are helix-turn-helix (HTH) repressors that bind DNA. Recently, Birkholz et al. discovered that an Aca can also repress Acr expression by binding RNA, revealing a new function for HTH repressors.
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Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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