Bovannak S Chap, Nicolas Rayroux, Alizée J Grimm, Eleonora Ghisoni, Denarda Dangaj Laniti
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引用次数: 0
摘要
卵巢癌（OC）代表着高度多样化的肿瘤微环境（TME）生态系统。肿瘤浸润淋巴细胞（TILs）的存在与增强的免疫反应和长期生存有关。在这篇综述中，我们介绍了新出现的证据，这些证据表明细胞间的串联密切调节着 TILs 在 TME 中的分布，强调了更好地了解促进或阻碍 T 细胞浸润 OC 的关键细胞网络的必要性。我们还捕捉了新出现的方法和计算技术，这些方法和技术有助于剖析细胞-细胞串联。最后，我们介绍了创新的体外 TME 模型，这些模型可用于绘制和扰乱细胞通讯，以增强 T 细胞浸润和免疫反应性。
Crosstalk of T cells within the ovarian cancer microenvironment.
Ovarian cancer (OC) represents ecosystems of highly diverse tumor microenvironments (TMEs). The presence of tumor-infiltrating lymphocytes (TILs) is linked to enhanced immune responses and long-term survival. In this review we present emerging evidence suggesting that cellular crosstalk tightly regulates the distribution of TILs within the TME, underscoring the need to better understand key cellular networks that promote or impede T cell infiltration in OC. We also capture the emergent methodologies and computational techniques that enable the dissection of cell-cell crosstalk. Finally, we present innovative ex vivo TME models that can be leveraged to map and perturb cellular communications to enhance T cell infiltration and immune reactivity.
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Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine.
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