Thaís da Silva Sabião , Ana Valer-Martínez , Carmen Sayon-Orea , Almudena Sanchez-Villegas , Juan José Pons , Júlia Cristina Cardoso Carraro , Miguel Ángel Martinez-Gonzalez , Maira Bes-Rastrollo
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引用次数: 0
摘要
本研究旨在调查西班牙大学毕业生前瞻性队列中预测的维生素 D 状态与抑郁症之间的关系。SUN 项目是一项动态队列研究,旨在调查健康和生活方式的多个方面。研究人员要求参与者填写一份包含 556 个项目的综合问卷,其中包括一份经过验证的食物频率问卷。最初没有抑郁症的参与者如果在随访期间报告了抑郁症的医学诊断,则被归类为偶发病例。血清中的维生素 D 水平是通过之前验证过的公式预测的。维生素D缺乏症的定义是维生素D水平低于20纳克/毫升。Cox模型用于估算调整后的危险比(HR)和95%置信区间(95% CI)。我们对 15,175 名西班牙大学毕业生(平均(标清)年龄:36.9 岁(11.5))进行了中位数为 12.7 年的随访。在 192,976 人年的随访中,我们发现了 753 例抑郁症病例。在对潜在的混杂因素进行调整后,维生素 D 缺乏者患抑郁症的风险比维生素 D 充足者高 27%(HR:1.27,95% CI:1.09-1.48;P = 0.002)。此外,还观察到女性性别对抑郁症风险的明显影响,女性缺乏维生素 D 的抑郁症风险高于男性(交互作用 p = 0.034)。在受过教育的西班牙中年人中,我们观察到维生素 D 缺乏与抑郁风险之间存在直接联系,而这在女性中更为明显。
Predicted vitamin D levels and risk of depression in the SUN Project: A prospective cohort study
The current study aimed to investigate the association between predicted vitamin D status and depression in a prospective Spanish cohort of university graduates. The SUN Project is a dynamic cohort study designed to investigate multiple aspects of health and lifestyle. Participants were asked to complete a comprehensive questionnaire consisting of 556 items, that included a validated food-frequency questionnaire. Participants initially free of depression were classified as incident cases if they reported a medical diagnosis of depression during follow-up. Serum vitamin D levels were predicted by a previously validated equation. Vitamin D deficiency was defined as vitamin D levels below 20 ng/mL. Cox models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI). We included 15,175 Spanish university graduates [mean (SD) age: 36.9 year (11.5)] followed-up for a median of 12.7 years. Among 192,976 person-years of follow-up, we identified 753 incident cases of depression. Participants with vitamin D deficiency had a 27% higher risk of depression as compared to those with vitamin D sufficiency (HR: 1.27, 95% CI: 1.09–1.48; p = 0.002) after adjusting for potential confounders. Furthermore, a significant effect modification by female sex was observed with higher depression risks associated with vitamin D deficiency in women than in men (p for interaction = 0.034). In educated middle-aged Spanish adults, we observed a direct association between vitamin D deficiency and the risk of depression, that was stronger among women.
期刊介绍:
Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research:
(1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors;
(2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology;
(3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;