植物天然产物生物合成的新趋势:化学视角

IF 8.3 2区 生物学 Q1 PLANT SCIENCES Current opinion in plant biology Pub Date : 2024-09-30 DOI:10.1016/j.pbi.2024.102649
Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir
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引用次数: 0

摘要

生物合成途径是将简单底物转化为更复杂结构的多步骤过程。在过去的二十年里,我们对这些途径的了解,尤其是对特殊植物代谢物的了解有了显著提高。这一突飞猛进得益于众多科学进步,如下一代测序、改进的分析平台和代谢物-转录物网络。通过公共数据库实现数据共享也促进了合作和知识传播。人们日益关注治疗性天然产品的供应及其对环境的影响,因此开始探索可持续的替代方法,如异源表达,这需要对这些途径有广泛的了解。在此,我们回顾了生物合成途径阐释的新兴方法及其有效整合的前景。
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Emerging trends in plant natural products biosynthesis: a chemical perspective
Biosynthetic pathways are multistep processes transforming simple substrates into more complex structures. Over the past two decades, our understanding of these pathways, especially for specialized plant metabolites, has significantly increased. This surge is due to numerous scientific advancements such as next-generation sequencing, improved analytical platforms, and metabolite-transcript networks. The uprising of data sharing through public databases has also fostered collaboration and knowledge dissemination. Growing concerns about the supply of therapeutic natural products and their environmental impact have led to exploring sustainable alternatives like heterologous expression, which requires extensive knowledge of these pathways. Herein, we review emerging approaches in biosynthetic pathway elucidations and their prospects for their efficient integration.
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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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