{"title":"痤疮和前列腺癌有什么联系？","authors":"Mark R. Goldstein , Luca Mascitelli","doi":"10.1016/j.mehy.2024.111495","DOIUrl":null,"url":null,"abstract":"<div><div>Acne and prostate cancer are in part indirectly connected by dietary characteristics that lead to overstimulation of cellular growth signaling. Further, they are directly connected by a proinflammatory phylotype of the acne related bacterium, <em>Cutibacterium acnes</em>, which spreads from acne affected skin to prostate tissue and exists there chronically within a biofilm it secretes, resulting in a local inflammatory and immunosuppressive microenvironment, eventually culminating in prostate cancer initiation and progression. The diet-acne-prostate cancer nexus needs to be explored further and has implications regarding diet, antibiotics, and vaccinations in the prevention and treatment of prostate cancer.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"192 ","pages":"Article 111495"},"PeriodicalIF":2.1000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"How might acne and prostate cancer be connected?\",\"authors\":\"Mark R. Goldstein , Luca Mascitelli\",\"doi\":\"10.1016/j.mehy.2024.111495\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Acne and prostate cancer are in part indirectly connected by dietary characteristics that lead to overstimulation of cellular growth signaling. Further, they are directly connected by a proinflammatory phylotype of the acne related bacterium, <em>Cutibacterium acnes</em>, which spreads from acne affected skin to prostate tissue and exists there chronically within a biofilm it secretes, resulting in a local inflammatory and immunosuppressive microenvironment, eventually culminating in prostate cancer initiation and progression. The diet-acne-prostate cancer nexus needs to be explored further and has implications regarding diet, antibiotics, and vaccinations in the prevention and treatment of prostate cancer.</div></div>\",\"PeriodicalId\":18425,\"journal\":{\"name\":\"Medical hypotheses\",\"volume\":\"192 \",\"pages\":\"Article 111495\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical hypotheses\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S030698772400238X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S030698772400238X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Acne and prostate cancer are in part indirectly connected by dietary characteristics that lead to overstimulation of cellular growth signaling. Further, they are directly connected by a proinflammatory phylotype of the acne related bacterium, Cutibacterium acnes, which spreads from acne affected skin to prostate tissue and exists there chronically within a biofilm it secretes, resulting in a local inflammatory and immunosuppressive microenvironment, eventually culminating in prostate cancer initiation and progression. The diet-acne-prostate cancer nexus needs to be explored further and has implications regarding diet, antibiotics, and vaccinations in the prevention and treatment of prostate cancer.
期刊介绍：
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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