{"title":"利用天然混合溶剂提取单锅细菌虾青素和开发可持续治疗产品的技术经济见解","authors":"","doi":"10.1016/j.seppur.2024.129926","DOIUrl":null,"url":null,"abstract":"<div><div>The increasing demand for sustainable and safe products is driving the replacement of synthetic pigments with natural alternatives in the cosmetics industry. Additionally, the use of green solvents, such as natural solvent mixtures (NaSoMix), is essential to minimize the environmental impact of extraction processes. This study explores the innovative application of NaSoMix for extracting astaxanthin-rich extracts (ARE) from the bacterium <em>Paracoccus carotinifaciens</em>, a promising source of natural colorants and antioxidants. By employing menthol-based natural deep eutectic solvents (NaDES) combined with bio-based solvents, <em>viz</em>., ethyl acetate and ethanol, the research achieved remarkable ARE extraction yields of up to 1.3 mg/mL using conventional procedures. Notably, process intensification through microwave-assisted extraction resulted in a 400 % increase in ARE recovery yields compared to traditional methods. The therapeutic soaps formulated with these ARE extracts exhibited significant antioxidant activity, achieving a 75 % reduction in DPPH• free radical signals, and maintained excellent color stability over a month, with minimal perceptual changes. Safety assessments confirmed the non-irritating properties of the therapeutic soaps, with an irritation score of 0 at low ARE concentrations. Furthermore, an economic analysis revealed a highly favorable Internal Rate of Return (IRR) of 183 % and a Return on Investment (ROI) of 2890 %, underscoring the commercial viability of this sustainable approach. Overall, this study highlights the effectiveness and safety of utilizing NaSoMix for extracting high-value compounds and formulating innovative therapeutic cosmetic products, aligning with consumer preferences for natural ingredients while promoting environmental sustainability and economic feasibility.</div></div>","PeriodicalId":427,"journal":{"name":"Separation and Purification Technology","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Techno-economic insights into one-pot bacterial astaxanthin extraction and sustainable therapeutic product development using natural solvent mixtures\",\"authors\":\"\",\"doi\":\"10.1016/j.seppur.2024.129926\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The increasing demand for sustainable and safe products is driving the replacement of synthetic pigments with natural alternatives in the cosmetics industry. Additionally, the use of green solvents, such as natural solvent mixtures (NaSoMix), is essential to minimize the environmental impact of extraction processes. This study explores the innovative application of NaSoMix for extracting astaxanthin-rich extracts (ARE) from the bacterium <em>Paracoccus carotinifaciens</em>, a promising source of natural colorants and antioxidants. By employing menthol-based natural deep eutectic solvents (NaDES) combined with bio-based solvents, <em>viz</em>., ethyl acetate and ethanol, the research achieved remarkable ARE extraction yields of up to 1.3 mg/mL using conventional procedures. Notably, process intensification through microwave-assisted extraction resulted in a 400 % increase in ARE recovery yields compared to traditional methods. The therapeutic soaps formulated with these ARE extracts exhibited significant antioxidant activity, achieving a 75 % reduction in DPPH• free radical signals, and maintained excellent color stability over a month, with minimal perceptual changes. Safety assessments confirmed the non-irritating properties of the therapeutic soaps, with an irritation score of 0 at low ARE concentrations. Furthermore, an economic analysis revealed a highly favorable Internal Rate of Return (IRR) of 183 % and a Return on Investment (ROI) of 2890 %, underscoring the commercial viability of this sustainable approach. Overall, this study highlights the effectiveness and safety of utilizing NaSoMix for extracting high-value compounds and formulating innovative therapeutic cosmetic products, aligning with consumer preferences for natural ingredients while promoting environmental sustainability and economic feasibility.</div></div>\",\"PeriodicalId\":427,\"journal\":{\"name\":\"Separation and Purification Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.1000,\"publicationDate\":\"2024-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Separation and Purification Technology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1383586624036657\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Separation and Purification Technology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1383586624036657","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0
摘要
化妆品行业对可持续和安全产品的需求日益增长,推动了天然替代品对合成颜料的替代。此外,使用绿色溶剂(如天然混合溶剂 (NaSoMix))对于最大限度地减少萃取过程对环境的影响至关重要。本研究探索了 NaSoMix 在从 Paracoccus carotinifaciens 细菌中提取富含虾青素的提取物 (ARE) 中的创新应用,这是一种很有前景的天然着色剂和抗氧化剂来源。通过采用薄荷醇基天然深共晶溶剂(NaDES)与生物基溶剂(即乙酸乙酯和乙醇)相结合的方法,该研究利用传统工艺实现了高达 1.3 mg/mL 的显著虾青素提取率。值得注意的是,与传统方法相比,通过微波辅助萃取强化工艺使 ARE 的回收率提高了 400%。用这些 ARE 提取物配制的治疗皂具有显著的抗氧化活性,可减少 75% 的 DPPH 自由基信号,并在一个月内保持良好的颜色稳定性,感观变化极小。安全评估证实了治疗皂的无刺激特性,在低浓度 ARE 的情况下刺激性为 0。此外,经济分析表明,该方法的内部收益率(IRR)为 183%,投资回报率(ROI)为 2890%,非常可观,凸显了这种可持续方法的商业可行性。总之,这项研究强调了利用 NaSoMix 提取高价值化合物和配制创新治疗化妆品的有效性和安全性,符合消费者对天然成分的偏好,同时促进了环境的可持续发展和经济可行性。
Techno-economic insights into one-pot bacterial astaxanthin extraction and sustainable therapeutic product development using natural solvent mixtures
The increasing demand for sustainable and safe products is driving the replacement of synthetic pigments with natural alternatives in the cosmetics industry. Additionally, the use of green solvents, such as natural solvent mixtures (NaSoMix), is essential to minimize the environmental impact of extraction processes. This study explores the innovative application of NaSoMix for extracting astaxanthin-rich extracts (ARE) from the bacterium Paracoccus carotinifaciens, a promising source of natural colorants and antioxidants. By employing menthol-based natural deep eutectic solvents (NaDES) combined with bio-based solvents, viz., ethyl acetate and ethanol, the research achieved remarkable ARE extraction yields of up to 1.3 mg/mL using conventional procedures. Notably, process intensification through microwave-assisted extraction resulted in a 400 % increase in ARE recovery yields compared to traditional methods. The therapeutic soaps formulated with these ARE extracts exhibited significant antioxidant activity, achieving a 75 % reduction in DPPH• free radical signals, and maintained excellent color stability over a month, with minimal perceptual changes. Safety assessments confirmed the non-irritating properties of the therapeutic soaps, with an irritation score of 0 at low ARE concentrations. Furthermore, an economic analysis revealed a highly favorable Internal Rate of Return (IRR) of 183 % and a Return on Investment (ROI) of 2890 %, underscoring the commercial viability of this sustainable approach. Overall, this study highlights the effectiveness and safety of utilizing NaSoMix for extracting high-value compounds and formulating innovative therapeutic cosmetic products, aligning with consumer preferences for natural ingredients while promoting environmental sustainability and economic feasibility.
期刊介绍:
Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.