绒毛膜羊膜炎对极早产儿产后生长的影响:一项基于日本人口的研究。

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-10-01 DOI:10.1007/s00404-024-07757-y
Takafumi Ushida, Rena Nosaka, Masahiro Nakatochi, Yumiko Kobayashi, Sho Tano, Kazuya Fuma, Seiko Matsuo, Kenji Imai, Yoshiaki Sato, Masahiro Hayakawa, Hiroaki Kajiyama, Tomomi Kotani
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引用次数: 0

摘要

目的:越来越多的证据表明,患有绒毛膜羊膜炎(CAM)的母亲所生的早产儿患各种新生儿疾病和长期神经系统疾病的风险增加;然而,CAM 对产后生长的影响仍未得到充分研究。本研究利用日本全国新生儿数据库评估了组织学 CAM 对极早产儿出生后生长轨迹的影响:方法:这项多中心回顾性研究使用了 4220 名体重小于 1500 克且在日本出生的早产儿的临床数据:多变量分析显示,组织学CAM与出生后体重(ΔZ-score)的加速增长有关(β系数[95%置信区间];0.10[0.00至0.20]),但与女性的身高无关(0.06[- 0.04至0.15]),与男性的身高和体重无关(分别为0.04[- 0.04至0.12]和0.02[- 0.07至0.11])。交互分析表明,在头三年中,组织学 CAM 对男婴和女婴身高和体重的 ΔZ 分数的影响没有显著差异(身高,p = 0.81;体重,p = 0.25):结论:宫内接触母体CAM会加速早产女婴出生后头三年的体重增加。
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Effect of chorioamnionitis on postnatal growth in very preterm infants: a population-based study in Japan.

Purpose: There is growing evidence that preterm infants born to mothers with chorioamnionitis (CAM) have increased risk of various neonatal morbidities and long-term neurological disorders; however, the effect of CAM on postnatal growth remains insufficiently investigated. This study evaluated the effect of histological CAM on postnatal growth trajectories in very preterm infants using a nationwide neonatal database in Japan.

Method: A multicenter retrospective study was conducted using clinical data of 4220 preterm neonates who weighed ≤ 1500 g and were born at < 32 weeks of gestation between 2003-2017 (CAM group: n = 2110; non-CAM group: n = 2110). Z-scores for height and weight were evaluated at birth and 3 years of age. Univariable and multivariable analyses were conducted to evaluate the effect of histological CAM on ΔZ-scores of height and weight during the first three years with a stratification by infant sex and the stage of histological CAM.

Results: Multivariable analyses showed that histological CAM was associated with accelerated postnatal increase (ΔZ-score) in weight (β coefficient [95% confidence interval]; 0.10 [0.00 to 0.20]), but not in height among females (0.06 [- 0.04 to 0.15]) and not in height and weight among males (0.04 [- 0.04 to 0.12] and 0.02 [- 0.07 to 0.11], respectively). An interaction analysis demonstrated no significant difference in the effect of histological CAM on the ΔZ-scores of height and weight during the first three years between male and female infants (height, p = 0.81; weight p = 0.25).

Conclusions: Intrauterine exposure to maternal CAM contributes to accelerated postnatal weight gain in female preterm infants during the first three years.

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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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