噬菌体疗法:对抗耐多药病原体的新方法。

IF 2.6 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 3 Biotech Pub Date : 2024-10-01 Epub Date: 2024-09-30 DOI:10.1007/s13205-024-04101-8
Arushi Kapoor, Samriti Balaji Mudaliar, Vyasraj G Bhat, Ishita Chakraborty, Alevoor Srinivas Bharath Prasad, Nirmal Mazumder
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引用次数: 0

摘要

耐多药(MDR)生物的迅速增加迫切需要替代治疗方案。噬菌体疗法通过使用溶解性噬菌体来特异性地靶向杀死有害细菌,作为抗击细菌感染的一种有效方法正日益受到关注。本综述讨论了几种噬菌体治疗方案,并强调了噬菌体生物学的新发展。多项人体临床试验表明,噬菌体疗法在治疗由这些病原体引起的一系列疾病方面取得了良好的效果,这也证明了噬菌体疗法能成功对付 MDR 细菌。尽管取得了这些令人鼓舞的成果,但噬菌体抗药性、监管障碍和标准化治疗方案需求等挑战依然存在。为了有效对抗 MDR 细菌感染,未来的研究必须侧重于提高噬菌体的有效性、保证人体使用的安全性以及将噬菌体疗法纳入临床实践。
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Phage therapy: A novel approach against multidrug-resistant pathogens.

The rapid rise of multidrug-resistant (MDR) organisms has created a critical need for alternative treatment options. Phage therapy is gaining attention as an effective way to fight bacterial infections by using lytic bacteriophages to specifically target and kill harmful bacteria. This review discusses several phage therapeutic options and emphasizes new developments in phage biology. Phage treatment has proven to be successful against MDR bacteria, as evidenced by multiple human clinical trials that indicate favorable results in treating a range of diseases caused by these pathogens. Despite these promising results, challenges such as phage resistance, regulatory hurdles, and the need for standardized treatment protocols remain. To effectively combat MDR bacterial infections, future research must focus on enhancing phage effectiveness, guaranteeing safety for human usage and incorporating phage therapy into clinical practice.

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来源期刊
3 Biotech
3 Biotech Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
6.00
自引率
0.00%
发文量
314
期刊介绍: 3 Biotech publishes the results of the latest research related to the study and application of biotechnology to: - Medicine and Biomedical Sciences - Agriculture - The Environment The focus on these three technology sectors recognizes that complete Biotechnology applications often require a combination of techniques. 3 Biotech not only presents the latest developments in biotechnology but also addresses the problems and benefits of integrating a variety of techniques for a particular application. 3 Biotech will appeal to scientists and engineers in both academia and industry focused on the safe and efficient application of Biotechnology to Medicine, Agriculture and the Environment.
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