Mark Bydder, Fadil Ali, Paul Condron, Daniel M Cornfeld, Gil Newburn, Eryn E Kwon, Maryam Tayebi, Miriam Scadeng, Tracy R Melzer, Samantha J Holdsworth, Graeme M Bydder
{"title":"使用标准 T1 模体验证超高对比度分减反转复原技术。","authors":"Mark Bydder, Fadil Ali, Paul Condron, Daniel M Cornfeld, Gil Newburn, Eryn E Kwon, Maryam Tayebi, Miriam Scadeng, Tracy R Melzer, Samantha J Holdsworth, Graeme M Bydder","doi":"10.1002/nbm.5269","DOIUrl":null,"url":null,"abstract":"<p><p>The divided subtracted inversion recovery (dSIR) is a high T<sub>1</sub> contrast technique that shows changes in white matter in patients with traumatic brain injury and hypoxic injury. The changes can be explained by small differences in T<sub>1</sub>; however, to date, there has been no independent validation of the technique using a standard reference. The present study develops the theory of the dSIR signal and performs validation using the NIST/ISMRM T<sub>1</sub> phantom. Non-idealities are explored, including the influence of noise bias and finite repetition time (TR), which leads to the introduction of an optimally efficient TR for inversion recovery acquisitions. Results show excellent agreement with theoretical calculations.</p>","PeriodicalId":19309,"journal":{"name":"NMR in Biomedicine","volume":" ","pages":"e5269"},"PeriodicalIF":2.7000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Validation of an ultrahigh contrast divided subtracted inversion recovery technique using a standard T<sub>1</sub> phantom.\",\"authors\":\"Mark Bydder, Fadil Ali, Paul Condron, Daniel M Cornfeld, Gil Newburn, Eryn E Kwon, Maryam Tayebi, Miriam Scadeng, Tracy R Melzer, Samantha J Holdsworth, Graeme M Bydder\",\"doi\":\"10.1002/nbm.5269\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The divided subtracted inversion recovery (dSIR) is a high T<sub>1</sub> contrast technique that shows changes in white matter in patients with traumatic brain injury and hypoxic injury. The changes can be explained by small differences in T<sub>1</sub>; however, to date, there has been no independent validation of the technique using a standard reference. The present study develops the theory of the dSIR signal and performs validation using the NIST/ISMRM T<sub>1</sub> phantom. Non-idealities are explored, including the influence of noise bias and finite repetition time (TR), which leads to the introduction of an optimally efficient TR for inversion recovery acquisitions. Results show excellent agreement with theoretical calculations.</p>\",\"PeriodicalId\":19309,\"journal\":{\"name\":\"NMR in Biomedicine\",\"volume\":\" \",\"pages\":\"e5269\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"NMR in Biomedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/nbm.5269\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"NMR in Biomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/nbm.5269","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Validation of an ultrahigh contrast divided subtracted inversion recovery technique using a standard T1 phantom.
The divided subtracted inversion recovery (dSIR) is a high T1 contrast technique that shows changes in white matter in patients with traumatic brain injury and hypoxic injury. The changes can be explained by small differences in T1; however, to date, there has been no independent validation of the technique using a standard reference. The present study develops the theory of the dSIR signal and performs validation using the NIST/ISMRM T1 phantom. Non-idealities are explored, including the influence of noise bias and finite repetition time (TR), which leads to the introduction of an optimally efficient TR for inversion recovery acquisitions. Results show excellent agreement with theoretical calculations.
期刊介绍:
NMR in Biomedicine is a journal devoted to the publication of original full-length papers, rapid communications and review articles describing the development of magnetic resonance spectroscopy or imaging methods or their use to investigate physiological, biochemical, biophysical or medical problems. Topics for submitted papers should be in one of the following general categories: (a) development of methods and instrumentation for MR of biological systems; (b) studies of normal or diseased organs, tissues or cells; (c) diagnosis or treatment of disease. Reports may cover work on patients or healthy human subjects, in vivo animal experiments, studies of isolated organs or cultured cells, analysis of tissue extracts, NMR theory, experimental techniques, or instrumentation.